Citric acid and itaconic acid accumulation: variations of the same story?

L. Karaffa, Christian P. Kubicek

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Citric acid production by Aspergillus niger and itaconic acid production by Aspergillus terreus are two major examples of technical scale fungal fermentations based on metabolic overflow of primary metabolism. Both organic acids are formed by the same metabolic pathway, but whereas citric acid is the end product in A. niger, A. terreus performs two additional enzymatic steps leading to itaconic acid. Despite of this high similarity, the optimization of the production process and the mechanism and regulation of overflow of these two acids has mostly been investigated independently, thereby ignoring respective knowledge from the other. In this review, we will highlight where the similarities and the real differences of these two processes occur, which involves various aspects of medium composition, metabolic regulation and compartmentation, transcriptional regulation, and gene evolution. These comparative data may facilitate further investigations of citric acid and itaconic acid accumulation and may contribute to improvements in their industrial production.

Original languageEnglish
JournalApplied Microbiology and Biotechnology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Citric Acid
Aspergillus niger
Acids
Aspergillus
Metabolic Networks and Pathways
Fermentation
Genes
itaconic acid

Keywords

  • Aspergillus niger
  • Aspergillus terreus
  • Citric acid
  • Itaconic acid
  • Overflow metabolism
  • Submerged fermentation

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Citric acid and itaconic acid accumulation : variations of the same story? / Karaffa, L.; Kubicek, Christian P.

In: Applied Microbiology and Biotechnology, 01.01.2019.

Research output: Contribution to journalReview article

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