Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: A pilot study

Yoshiyuki Kita, G. Holló, Akiko Murai, Ritsuko Kita, Tsunehiro Saito, Akito Hirakata

Research output: Contribution to journalArticle

Abstract

Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector). Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma.

Original languageEnglish
Pages (from-to)2535-2544
Number of pages10
JournalClinical Ophthalmology
Volume12
DOIs
Publication statusPublished - Jan 1 2018

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Optical Coherence Tomography
Glaucoma
Retina
Ganglia
Nerve Fibers
Healthy Volunteers

Keywords

  • Circumpapillary ganglion-cell complex
  • Circumpapillary retinal nerve-fiber-layer thickness
  • Circumpapillary total retina thickness
  • Glaucoma
  • Microperimetry sensitivity
  • Structure-function relationship

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma : A pilot study. / Kita, Yoshiyuki; Holló, G.; Murai, Akiko; Kita, Ritsuko; Saito, Tsunehiro; Hirakata, Akito.

In: Clinical Ophthalmology, Vol. 12, 01.01.2018, p. 2535-2544.

Research output: Contribution to journalArticle

Kita, Yoshiyuki ; Holló, G. ; Murai, Akiko ; Kita, Ritsuko ; Saito, Tsunehiro ; Hirakata, Akito. / Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma : A pilot study. In: Clinical Ophthalmology. 2018 ; Vol. 12. pp. 2535-2544.
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AU - Kita, Yoshiyuki

AU - Holló, G.

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AU - Saito, Tsunehiro

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AB - Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector). Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma.

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KW - Structure-function relationship

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