Abstract
Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector). Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma.
| Original language | English |
|---|---|
| Pages (from-to) | 2535-2544 |
| Number of pages | 10 |
| Journal | Clinical Ophthalmology |
| Volume | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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Keywords
- Circumpapillary ganglion-cell complex
- Circumpapillary retinal nerve-fiber-layer thickness
- Circumpapillary total retina thickness
- Glaucoma
- Microperimetry sensitivity
- Structure-function relationship
ASJC Scopus subject areas
- Ophthalmology
Cite this
Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma : A pilot study. / Kita, Yoshiyuki; Holló, G.; Murai, Akiko; Kita, Ritsuko; Saito, Tsunehiro; Hirakata, Akito.
In: Clinical Ophthalmology, Vol. 12, 01.01.2018, p. 2535-2544.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma
T2 - A pilot study
AU - Kita, Yoshiyuki
AU - Holló, G.
AU - Murai, Akiko
AU - Kita, Ritsuko
AU - Saito, Tsunehiro
AU - Hirakata, Akito
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector). Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma.
AB - Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector). Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma.
KW - Circumpapillary ganglion-cell complex
KW - Circumpapillary retinal nerve-fiber-layer thickness
KW - Circumpapillary total retina thickness
KW - Glaucoma
KW - Microperimetry sensitivity
KW - Structure-function relationship
UR - http://www.scopus.com/inward/record.url?scp=85059457169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059457169&partnerID=8YFLogxK
U2 - 10.2147/OPTH.S186739
DO - 10.2147/OPTH.S186739
M3 - Article
AN - SCOPUS:85059457169
VL - 12
SP - 2535
EP - 2544
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
SN - 1177-5467
ER -