Circulatory support for long-term treatment of heart failure: Experience with an intraventricular continuous flow pump

Stephen Westaby, Adrian P. Banning, Satoshi Saito, David W. Pigott, Xu Y. Jin, Pedro A. Catarino, Desiree Robson, Narain Moorjani, Attila Kardos, Philip A. Poole-Wilson, Robert Jarvik, O. H. Frazier

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background - A lifetime mechanical solution for advanced heart failure must be reliable, with a low risk of life-threatening complications. After extensive laboratory testing, we began clinical trials with an axial flow pump for long-term treatment of New York Heart Association class IV, transplant-ineligible patients. Methods and Results - The Jarvik 2000 is a continuous flow device that is implanted in the apex of the left ventricle with offloading to the descending thoracic aorta. Skull-based percutaneous power delivery was derived from cochlear implant technology. We used this system in 4 patients with end-stage dilated cardiomyopathy. Exercise capacity, quality of life, device parameters, and native heart function were monitored serially. One patient died from right heart failure at 3 months. The other patients were discharged from hospital between 3 and 8 weeks postoperatively and are currently New York Heart Association I or II. Follow-up lasted between 9 and 20 months. There has been no device failure or hemolysis. Native heart function and quality of life were markedly improved. Conclusions - The Jarvik 2000 is a true assist (rather than replacement) device that functions synergistically with the native left ventricle and provides excellent quality of life. Adverse events are infrequent. This blood pump may provide a mechanical solution for end-stage heart failure in the community.

Original languageEnglish
Pages (from-to)2588-2591
Number of pages4
JournalCirculation
Volume105
Issue number22
DOIs
Publication statusPublished - Jun 5 2002

Keywords

  • Blood flow
  • Heart failure
  • Heart-assist device

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Westaby, S., Banning, A. P., Saito, S., Pigott, D. W., Jin, X. Y., Catarino, P. A., Robson, D., Moorjani, N., Kardos, A., Poole-Wilson, P. A., Jarvik, R., & Frazier, O. H. (2002). Circulatory support for long-term treatment of heart failure: Experience with an intraventricular continuous flow pump. Circulation, 105(22), 2588-2591. https://doi.org/10.1161/01.CIR.0000018165.24503.5B