Circulatory effects of intraduodenal acidification in the rat

I. Benyó, A. Fazekas, E. Pósch, L. Rosivall, G. Szabó

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of intraduodenal administration of 0.3 ml/100 g 0.1 N hydrochloric acid and of the i.v. injection of 0.3 U/100 g secretin on the regional circulation was investigated in rats with the radioactive microsphere method. Intraduodenal acid produced a threefold increase in duodenal blood flow, jejunal perfusion was doubled, the perfusion of pancreas increased significantly. There were no significant changes in cardiac output, renal, myocardial, gastric and ileal blood flow. Secretin administration was without effect on the circulation. The same hormone dose produced a tenfold increase in pancreas secretion but was without effect on bile output. It is concluded that in the rat low doses of secretin do not elicit mesenteric flow changes similar to those observed after duodenal acidification.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalResearch in Experimental Medicine
Volume177
Issue number3
DOIs
Publication statusPublished - Oct 1980

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Secretin
Pancreas
Perfusion
Hydrochloric Acid
Microspheres
Bile
Cardiac Output
Stomach
Hormones
Kidney
Injections
Acids

Keywords

  • Duodenal acidification
  • Flow changes after intraduodenal acid and secretin
  • Radioactive microspheres
  • Secretin and regional blood flow

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Circulatory effects of intraduodenal acidification in the rat. / Benyó, I.; Fazekas, A.; Pósch, E.; Rosivall, L.; Szabó, G.

In: Research in Experimental Medicine, Vol. 177, No. 3, 10.1980, p. 221-226.

Research output: Contribution to journalArticle

Benyó, I. ; Fazekas, A. ; Pósch, E. ; Rosivall, L. ; Szabó, G. / Circulatory effects of intraduodenal acidification in the rat. In: Research in Experimental Medicine. 1980 ; Vol. 177, No. 3. pp. 221-226.
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