Circulating tumor-cell detection and capture using microfluidic devices

Laszlo Hajba, A. Guttman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Circulating tumor cells (CTCs) in the bloodstream are considered good indicators of the presence of a primary tumor or even metastases. CTC capture has great importance in early detection of cancer, especially in identifying novel therapeutic routes for cancer patients by finding personalized druggable targets for the pharmaceutical industry. Recent developments in microfluidics and nanotechnology improved the capabilities of CTC detection and capture, including purity, selectivity and throughput. This article covers the recent technological improvements in microfluidics-based CTC-capture methods utilizing the physical and biochemical properties of CTCs. We critically review the most promising hydrodynamic, dielectrophoretic and magnetic force-based microfluidic CTC-capture devices.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalTrAC - Trends in Analytical Chemistry
Volume59
DOIs
Publication statusPublished - 2014

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Microfluidics
tumor
Tumors
cancer
capture method
pharmaceutical industry
nanotechnology
detection
Nanotechnology
Hydrodynamics
hydrodynamics
Cells
Throughput
Pharmaceutical Preparations
Industry

Keywords

  • Cancer-therapy management
  • Circulating tumor cell (CTC)
  • CTC capture
  • CTC detection
  • Dielectrophoresis
  • Early detection
  • Hydrodynamics
  • Metastases
  • Microfluidics
  • Nanotechnology

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Circulating tumor-cell detection and capture using microfluidic devices. / Hajba, Laszlo; Guttman, A.

In: TrAC - Trends in Analytical Chemistry, Vol. 59, 2014, p. 9-16.

Research output: Contribution to journalArticle

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