Circulating S100B is increased after bilateral femur fracture without brain injury in the rat

Linda E. Pelinka, L. Szalay, M. Jafarmadar, R. Schmidhammer, H. Redl, S. Bahrami

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background. S100B is an acknowledged marker of brain damage. However, trauma without brain damage also causes an increase in S100B. S100B concentrations are highest in multiple trauma patients with long bone fractures. Clinically, extensive long bone fractures are associated with haemorrhagic shock and haemorrhagic shock per se is associated with increased S100B. The aim of our experimental study was to verify the S100B increase in long bone fracture without haemorrhagic shock. Methods and Results. Bilateral femur fracture was carried out in 10 anaesthetized rats. Blood samples were drawn for immuno-luminometrical S100B measurement 5, 15, 30, 120, and 240 min after fracture. Mean arterial pressure (MAP), heart rate, and body temperature were monitored continuously. S100B increased after bilateral femur fracture and reached a peak 30-120 min after fracture (P<0.001). MAP remained at a level which is not associated with shock in rats. Heart rate and body temperature remained unchanged. Autopsy verified open bilateral femur fracture surrounded only by small zones of clotted blood. Conclusions. S100B is increased in bilateral femur fracture without haemorrhagic shock in rats. This finding suggests that bone marrow is a potential extracerebral source of S100B.

Original languageEnglish
Pages (from-to)595-597
Number of pages3
JournalBritish Journal of Anaesthesia
Volume91
Issue number4
DOIs
Publication statusPublished - Oct 1 2003

Keywords

  • Blood, protein S100
  • Brain, traumatic injury
  • Complications, long bone injury

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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