Keringo mikroRNS-ek az endokrin daganatok diagnosztikájában

Translated title of the contribution: Circulating microRNAs in the diagnostics of endocrine neoplasms

Decmann Ábel, Perge Pál, Nagy Zoltán, Butz Henriett, A. Patócs, P. Igaz

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

MicroRNAs (miRNA, miR) are short - 19-25 nucleotide long - single stranded (in their mature form), non-coding RNA molecules that regulate gene expression mostly at the posttranscriptional level. microRNAs are involved in the regulation of various physiological processes such as cell differentiation and proliferation, development, haematopoesis, cell death, while their aberrant expression is observed in numerous diseases, like autoimmune disorders, infammations, vascular diseases or tumorigenesis. microRNAs are expressed in a tissue specifc fashion. Beyond their appearance in tissues, they can be found in body fuids as well. microRNAs are present in blood, mother milk, semen, saliva, urine, etc. MicroRNAs in body fuids, especially the blood-borne circulating microRNAs can be exploited as minimally invasive biomarkers of tumor diagnosis. The number of endocrine tumor-associated circulating microRNA alterations is relatively low, mostly described for papillary thyroid cancer, adrenocortical cancer, ovarian and neuroendocrine tumors. As the histological diagnosis including the establishment of malignancy of some of these neoplasms is diffcult, studies on circulating microRNAs might have great perspectives.

Original languageHungarian
Pages (from-to)483-490
Number of pages8
JournalOrvosi Hetilap
Volume158
Issue number13
DOIs
Publication statusPublished - Apr 1 2017

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ASJC Scopus subject areas

  • Medicine(all)

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