Circulating levels of the anti-angiogenic thrombospondin 2 are elevated in pre-eclampsia

Balázs Stenczer, A. Molvarec, Zoltán Veresh, Nóra Gullai, Gyula Richárd Nagy, Szilvia Walentin, János SzijártÓ, J. Rigó

Research output: Contribution to journalArticle

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Abstract

An imbalance of maternal circulating pro- and anti-angiogenic factors may play a role in the pathogenesis of pre-eclampsia. Thrombospondin 2 (TSP-2) is a protein expressed mainly by activated endothelial cells, which acts as a potent anti-angiogenic agent. Our aim was to determine whether serum TSP-2 levels are altered in pre-eclampsia. We enrolled 35 pre-eclamptic patients and 35 healthy pregnant women in the study. Thrombospondin 2 levels were determined by enzyme-linked immunosorbent assay, while soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) concentrations were determined by electrochemiluminescence immunoassay. In patients with PE, we demonstrated 1.7-fold higher TSP-2 [13.2 (9.4-18.1) vs. 7.9 (7.2-11.2) ng/ml, p

Original languageEnglish
Pages (from-to)1291-1295
Number of pages5
JournalActa Obstetricia et Gynecologica Scandinavica
Volume90
Issue number11
DOIs
Publication statusPublished - Nov 2011

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Pre-Eclampsia
Vascular Endothelial Growth Factor Receptor-1
Angiogenesis Inducing Agents
Immunoassay
Pregnant Women
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Enzyme-Linked Immunosorbent Assay
Mothers
thrombospondin 2
Serum
Proteins

Keywords

  • Angiogenesis inhibitor
  • placental growth factor
  • pre-eclampsia
  • pregnancy
  • soluble vascular endothelial growth factor receptor-1
  • thrombospondin 2

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Circulating levels of the anti-angiogenic thrombospondin 2 are elevated in pre-eclampsia. / Stenczer, Balázs; Molvarec, A.; Veresh, Zoltán; Gullai, Nóra; Nagy, Gyula Richárd; Walentin, Szilvia; SzijártÓ, János; Rigó, J.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 90, No. 11, 11.2011, p. 1291-1295.

Research output: Contribution to journalArticle

Stenczer, Balázs ; Molvarec, A. ; Veresh, Zoltán ; Gullai, Nóra ; Nagy, Gyula Richárd ; Walentin, Szilvia ; SzijártÓ, János ; Rigó, J. / Circulating levels of the anti-angiogenic thrombospondin 2 are elevated in pre-eclampsia. In: Acta Obstetricia et Gynecologica Scandinavica. 2011 ; Vol. 90, No. 11. pp. 1291-1295.
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