Circulating levels of placental protein 12 (PP 12) in diabetic pregnancy complicated by retinopathy

V. Briese, G. Than, D. G. Szabo, A. Szilagyi, R. R. Strache, P. Heinke, H. Hopp, H. H. Buttner

Research output: Contribution to journalArticle

Abstract

Placental protein 12 (PP 12) is a soluble tissue antigen. Immunohistochemical studies have localized PP 12 in the placental syncytiotrophoblast, chorion and amnion, and also in the decidua. During normal pregnancy serum-PP 12 is already raised in the first trimester, there is then a peak at 18 weeks, a gradual fall until 32 weeks, and a moderate increase thereafter. The mean of the healthy control group at 18 weeks of pregnancy was 122.9 ± 47.5 μg/l. The mean of the diabetic group with retinopathy at the same time was 192.2 ± 78.8 μg/l. There was no significant difference between background retinopathy and the proliferative form of diabetic retinopathy. At all times during pregnancy the median values of PP 12 in diabetic pregnancies were significantly (p <0.01) above the control values. Increased PP 12 levels in diabetic pregnancy complicated by retinopathy are probably caused by decidual, placental and amniotic leakages.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalExperimental and Clinical Endocrinology
Volume95
Issue number1
Publication statusPublished - 1990

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Pregnancy Proteins
Pregnancy in Diabetics
Chorion
Decidua
Pregnancy
Amnion
Trophoblasts
Diabetic Retinopathy
First Pregnancy Trimester
Blood Proteins
Antigens
Control Groups

Keywords

  • placental protein 12 (PP 12)
  • PP 12 serum levels in high risk pregnancies-PP 12 in diabetic retinopathy

ASJC Scopus subject areas

  • Endocrinology

Cite this

Briese, V., Than, G., Szabo, D. G., Szilagyi, A., Strache, R. R., Heinke, P., ... Buttner, H. H. (1990). Circulating levels of placental protein 12 (PP 12) in diabetic pregnancy complicated by retinopathy. Experimental and Clinical Endocrinology, 95(1), 105-109.

Circulating levels of placental protein 12 (PP 12) in diabetic pregnancy complicated by retinopathy. / Briese, V.; Than, G.; Szabo, D. G.; Szilagyi, A.; Strache, R. R.; Heinke, P.; Hopp, H.; Buttner, H. H.

In: Experimental and Clinical Endocrinology, Vol. 95, No. 1, 1990, p. 105-109.

Research output: Contribution to journalArticle

Briese, V, Than, G, Szabo, DG, Szilagyi, A, Strache, RR, Heinke, P, Hopp, H & Buttner, HH 1990, 'Circulating levels of placental protein 12 (PP 12) in diabetic pregnancy complicated by retinopathy', Experimental and Clinical Endocrinology, vol. 95, no. 1, pp. 105-109.
Briese, V. ; Than, G. ; Szabo, D. G. ; Szilagyi, A. ; Strache, R. R. ; Heinke, P. ; Hopp, H. ; Buttner, H. H. / Circulating levels of placental protein 12 (PP 12) in diabetic pregnancy complicated by retinopathy. In: Experimental and Clinical Endocrinology. 1990 ; Vol. 95, No. 1. pp. 105-109.
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