Circulating endothelial progenitor cells and depression: A possible novel link between heart and soul

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78 Citations (Scopus)

Abstract

Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+VEGFR2+) and immature (CD133+ VEGFR2+) EPC counts were decreased in patients (vs controls; P

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalMolecular Psychiatry
Volume14
Issue number5
DOIs
Publication statusPublished - May 2009

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Vascular Endothelial Growth Factor Receptor-2
Flow Cytometry
Cell Count
Endothelial Progenitor Cells
Antibodies

Keywords

  • Cardiovascular diseases
  • Depression
  • Endothelial progenitor cells
  • Mood disorders
  • Postnatal vasculogenesi

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

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abstract = "Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34+VEGFR2+) and immature (CD133+ VEGFR2+) EPC counts were decreased in patients (vs controls; P",
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AU - Teleki, Z.

AU - Ríhmer, Z.

AU - Peter, L.

AU - Dobos, J.

AU - Kenessey, I.

AU - Tóvári, J.

AU - Tímár, J.

AU - Paku, S.

AU - Kovacs, G.

AU - Döme, B.

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