Circulating endothelial cell count, plasma vWF and soluble ICAM-1 levels following primary or elective percutaneous coronary intervention

K. Vargová, E. Tóth-Zsámboki, B. J. Beres, J. Bencze, G. Kerecsen, P. Gulacsi-Bardos, R. Kiss, I. Préda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Percutaneous coronary intervention (PCI) is an important therapeutic strategy in patients with ischaemic heart disease. Our aim was to clarify the extent of endothelial injury induced by PCI in stable angina (SA) or in acute ST-elevation myocardial infarction (STEMI). Methods: Circulating endothelial cell (CEC) count, von Willebrand factor (vWF) and soluble intercellular adhesion molecule-1 (sICAM-1) levels were determined pre-, post-, 24 and 96 h after PCI in patients with SA (n = 23) and with STEMI (n = 28). To provide control data regarding the effect of angiography itself stable angina patients with coronarography only (n = 23) were enrolled. Results: PCI and coronarography in stable angina patients caused measurable, but only non-significant elevation of CEC count and plasma vWF (p = NS). In STEMI, significantly higher baseline CEC count (p = 0.019) and vWF plasma levels (p = 0.046) were found compared to SA with PCI/or coronarography. After PCI, explicit increase in CEC count was observed (significant peak at 24 h) (p = 0.036). Positive correlation was found between baseline CKMB and CEC count at 24 h (r = 0.51, p <0.05). Conclusion: Both coronary angiography and elective PCI cause only mild endothelial injury. However, in patients with STEMI, not only the procedure itself but myocardial ischemia and the ongoing atherothrombotic process might be responsible for the prolonged and more pronounced endothelial damage.

Original languageEnglish
Pages (from-to)366-372
Number of pages7
JournalAtherosclerosis
Volume198
Issue number2
DOIs
Publication statusPublished - Jun 2008

Fingerprint

von Willebrand Factor
Intercellular Adhesion Molecule-1
Percutaneous Coronary Intervention
Stable Angina
Endothelial Cells
Cell Count
Myocardial Ischemia
Wounds and Injuries
Coronary Angiography
Angiography
ST Elevation Myocardial Infarction

Keywords

  • Circulating endothelial cell count
  • Ischemic heart disease
  • Percutaneous coronary intervention
  • Soluble intercellular adhesion molecule-1
  • STEMI
  • von Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Circulating endothelial cell count, plasma vWF and soluble ICAM-1 levels following primary or elective percutaneous coronary intervention. / Vargová, K.; Tóth-Zsámboki, E.; Beres, B. J.; Bencze, J.; Kerecsen, G.; Gulacsi-Bardos, P.; Kiss, R.; Préda, I.

In: Atherosclerosis, Vol. 198, No. 2, 06.2008, p. 366-372.

Research output: Contribution to journalArticle

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AU - Vargová, K.

AU - Tóth-Zsámboki, E.

AU - Beres, B. J.

AU - Bencze, J.

AU - Kerecsen, G.

AU - Gulacsi-Bardos, P.

AU - Kiss, R.

AU - Préda, I.

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N2 - Background: Percutaneous coronary intervention (PCI) is an important therapeutic strategy in patients with ischaemic heart disease. Our aim was to clarify the extent of endothelial injury induced by PCI in stable angina (SA) or in acute ST-elevation myocardial infarction (STEMI). Methods: Circulating endothelial cell (CEC) count, von Willebrand factor (vWF) and soluble intercellular adhesion molecule-1 (sICAM-1) levels were determined pre-, post-, 24 and 96 h after PCI in patients with SA (n = 23) and with STEMI (n = 28). To provide control data regarding the effect of angiography itself stable angina patients with coronarography only (n = 23) were enrolled. Results: PCI and coronarography in stable angina patients caused measurable, but only non-significant elevation of CEC count and plasma vWF (p = NS). In STEMI, significantly higher baseline CEC count (p = 0.019) and vWF plasma levels (p = 0.046) were found compared to SA with PCI/or coronarography. After PCI, explicit increase in CEC count was observed (significant peak at 24 h) (p = 0.036). Positive correlation was found between baseline CKMB and CEC count at 24 h (r = 0.51, p <0.05). Conclusion: Both coronary angiography and elective PCI cause only mild endothelial injury. However, in patients with STEMI, not only the procedure itself but myocardial ischemia and the ongoing atherothrombotic process might be responsible for the prolonged and more pronounced endothelial damage.

AB - Background: Percutaneous coronary intervention (PCI) is an important therapeutic strategy in patients with ischaemic heart disease. Our aim was to clarify the extent of endothelial injury induced by PCI in stable angina (SA) or in acute ST-elevation myocardial infarction (STEMI). Methods: Circulating endothelial cell (CEC) count, von Willebrand factor (vWF) and soluble intercellular adhesion molecule-1 (sICAM-1) levels were determined pre-, post-, 24 and 96 h after PCI in patients with SA (n = 23) and with STEMI (n = 28). To provide control data regarding the effect of angiography itself stable angina patients with coronarography only (n = 23) were enrolled. Results: PCI and coronarography in stable angina patients caused measurable, but only non-significant elevation of CEC count and plasma vWF (p = NS). In STEMI, significantly higher baseline CEC count (p = 0.019) and vWF plasma levels (p = 0.046) were found compared to SA with PCI/or coronarography. After PCI, explicit increase in CEC count was observed (significant peak at 24 h) (p = 0.036). Positive correlation was found between baseline CKMB and CEC count at 24 h (r = 0.51, p <0.05). Conclusion: Both coronary angiography and elective PCI cause only mild endothelial injury. However, in patients with STEMI, not only the procedure itself but myocardial ischemia and the ongoing atherothrombotic process might be responsible for the prolonged and more pronounced endothelial damage.

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KW - Soluble intercellular adhesion molecule-1

KW - STEMI

KW - von Willebrand factor

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