Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy

Brigitta Dombai, István Ivancsó, András Bikov, Dóra Oroszi, Anikó Bohács, V. Müller, J. Rigó, B. Vásárhelyi, G. Losonczy, L. Tamási

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Abstract

Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL, p=0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml, p=0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (p=0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] μg/mL, p=0.8730) and the level was lower in HP (98.80 [84.26-105.5] μg/mL, p=0.0344 versus HNP). In contrast, the level was higher in AP (111.7 [98.84-125.6] μg/mL, p=0.0091 versus HP). In ANP, a positive correlation of PEF (r=0.3405; p=0.0221) and a negative correlation of Raw (r=-0.3723; p=0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function.

Original languageEnglish
Article number1602039
JournalCanadian Respiratory Journal
Volume2017
DOIs
Publication statusPublished - Jan 1 2017

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Clusterin
Osteopontin
Asthma
Pregnancy
Pregnant Women
Cross-Sectional Studies
Biomarkers
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy. / Dombai, Brigitta; Ivancsó, István; Bikov, András; Oroszi, Dóra; Bohács, Anikó; Müller, V.; Rigó, J.; Vásárhelyi, B.; Losonczy, G.; Tamási, L.

In: Canadian Respiratory Journal, Vol. 2017, 1602039, 01.01.2017.

Research output: Contribution to journalArticle

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abstract = "Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1.680-2.331] ng/mL, p=0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439-4.015] ng/ml, p=0.003 versus HNP) and asthmatic (AP: 2.693 [1.581-3.620] ng/ml) patients; thus the pregnant groups did not differ (p=0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59-116.3] versus 108.8 [97.94-115.3] μg/mL, p=0.8730) and the level was lower in HP (98.80 [84.26-105.5] μg/mL, p=0.0344 versus HNP). In contrast, the level was higher in AP (111.7 [98.84-125.6] μg/mL, p=0.0091 versus HP). In ANP, a positive correlation of PEF (r=0.3405; p=0.0221) and a negative correlation of Raw (r=-0.3723; p=0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function.",
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AU - Oroszi, Dóra

AU - Bohács, Anikó

AU - Müller, V.

AU - Rigó, J.

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