Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer

Tibor Szarvas, Tobias Jäger, Viktoria Laszlo, Gero Kramer, H. Christoph Klingler, Frank Vom Dorp, I. Romics, Süleyman Ergün, Herbert Rübben

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Abstract

To assess the role and prognostic significance of angiostatin, basic fibroblast growth factor (bFGF), and tyrosine endothelial kinase (TEK/Tie2) in transitional cell bladder carcinoma. Angiostatin, bFGF, and TEK serum concentrations were measured in 82 bladder cancer patients and 20 age-matched healthy controls using enzyme-linked immunosorbent assay. Results were compared with clinicopathologic and follow-up data with the Mann-Whitney U test and Kaplan-Meier, univariate and multivariate Cox regression analyses. We found significantly decreased angiostatin and TEK serum levels and mildly elevated bFGF concentrations in samples of bladder cancer patients compared with controls (P <.001, P <.001, and P = .083, respectively). Furthermore, high TEK serum levels were correlated with poor disease-specific and metastasis-free survival in muscle-invasive bladder cancer (P = .013, P = .018), whereas angiostatin and bFGF concentrations did not show any correlation with patients' prognosis. Multivariate analysis revealed high TEK levels (

Original languageEnglish
JournalUrology
Volume80
Issue number3
DOIs
Publication statusPublished - Sep 2012

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Angiostatins
Fibroblast Growth Factor 2
Urinary Bladder Neoplasms
Serum
Transitional Cell Carcinoma
Nonparametric Statistics
Protein-Tyrosine Kinases
Urinary Bladder
Multivariate Analysis
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Neoplasm Metastasis
Muscles
Survival

ASJC Scopus subject areas

  • Urology

Cite this

Szarvas, T., Jäger, T., Laszlo, V., Kramer, G., Klingler, H. C., Vom Dorp, F., ... Rübben, H. (2012). Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer. Urology, 80(3). https://doi.org/10.1016/j.urology.2012.03.023

Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer. / Szarvas, Tibor; Jäger, Tobias; Laszlo, Viktoria; Kramer, Gero; Klingler, H. Christoph; Vom Dorp, Frank; Romics, I.; Ergün, Süleyman; Rübben, Herbert.

In: Urology, Vol. 80, No. 3, 09.2012.

Research output: Contribution to journalArticle

Szarvas, T, Jäger, T, Laszlo, V, Kramer, G, Klingler, HC, Vom Dorp, F, Romics, I, Ergün, S & Rübben, H 2012, 'Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer', Urology, vol. 80, no. 3. https://doi.org/10.1016/j.urology.2012.03.023
Szarvas, Tibor ; Jäger, Tobias ; Laszlo, Viktoria ; Kramer, Gero ; Klingler, H. Christoph ; Vom Dorp, Frank ; Romics, I. ; Ergün, Süleyman ; Rübben, Herbert. / Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer. In: Urology. 2012 ; Vol. 80, No. 3.
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