Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

Gábor Földes, F. Horkay, I. Szokodi, Olli Vuolteenaho, Mika Ilves, Ken A. Lindstedt, Mikko Mäyränpää, Balázs Sármán, Leila Seres, R. Skoumal, Zoltán Lakó-Futó, Rudolf DeChâtel, Heikki Ruskoaho, Miklós Tóth

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

The orphan receptor APJ and its recently identified endogenous ligand, apelin, are expressed in the heart. However, their importance in the human cardiovascular system is not known. This study shows that apelin-like immunoreactivity is abundantly present in healthy human heart and plasma. Gel filtration HPLC analysis revealed that atrial and plasma levels of high molecular weight apelin, possibly proapelin, were markedly higher than those of mature apelin-36 itself. As assessed by quantitative RT-PCR analysis, left ventricular apelin mRNA levels were increased 4.7-fold in chronic heart failure (CHF) due to coronary heart disease (p

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume308
Issue number3
DOIs
Publication statusPublished - Aug 29 2003

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Heart Failure
Ligands
Cardiovascular System
Gel Chromatography
Coronary Disease
Molecular Weight
High Pressure Liquid Chromatography
Plasmas
Cardiovascular system
Polymerase Chain Reaction
Messenger RNA
Gels
Molecular weight

Keywords

  • Apelin
  • APJ receptor
  • Heart failure
  • Human

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. / Földes, Gábor; Horkay, F.; Szokodi, I.; Vuolteenaho, Olli; Ilves, Mika; Lindstedt, Ken A.; Mäyränpää, Mikko; Sármán, Balázs; Seres, Leila; Skoumal, R.; Lakó-Futó, Zoltán; DeChâtel, Rudolf; Ruskoaho, Heikki; Tóth, Miklós.

In: Biochemical and Biophysical Research Communications, Vol. 308, No. 3, 29.08.2003, p. 480-485.

Research output: Contribution to journalArticle

Földes, G, Horkay, F, Szokodi, I, Vuolteenaho, O, Ilves, M, Lindstedt, KA, Mäyränpää, M, Sármán, B, Seres, L, Skoumal, R, Lakó-Futó, Z, DeChâtel, R, Ruskoaho, H & Tóth, M 2003, 'Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure', Biochemical and Biophysical Research Communications, vol. 308, no. 3, pp. 480-485. https://doi.org/10.1016/S0006-291X(03)01424-4
Földes, Gábor ; Horkay, F. ; Szokodi, I. ; Vuolteenaho, Olli ; Ilves, Mika ; Lindstedt, Ken A. ; Mäyränpää, Mikko ; Sármán, Balázs ; Seres, Leila ; Skoumal, R. ; Lakó-Futó, Zoltán ; DeChâtel, Rudolf ; Ruskoaho, Heikki ; Tóth, Miklós. / Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. In: Biochemical and Biophysical Research Communications. 2003 ; Vol. 308, No. 3. pp. 480-485.
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