Circadian rhythm of hyaluronan in serum during bedrest and controlled food intake

A. Roessler, E. Kvas, Z. László, H. G. Hinghofer-Szalkay

Research output: Contribution to journalArticle

Abstract

Diurnal variations in hyaluronan (HA) content in serum are described, however these changes are believed lo exist due to morning activity or physical exercise. Our study was designed to determine if 1) circadian rhythm in HA content exists without physical activity and in if 2) peaks in HA concentrations are due to food intake. Consequently we measured HA concentrations in plasma in a 30 min. interval in 4 test subjects during a one day bedrest period under standardized conditions, which represent either three times food intake per day or small meals distributed by 30 min. intervals during the whole experiment. HA was measured by a sensitive immunoassay developed in our lab, which is based on the affinity of proteoglycan to HA and possesses a sensitivity of 0.24μg/L. Meals three times a day led to elevations in HA concentration immediately after eating with a major peak at 9:30, which confirms other publications. In contrast continues feeding resulted in maintaining a constant daily HA level except a reproducible elevation after waking up. We conclude that circadian rhythms in HA mainly depend on food intake as well as physical activity. Without both stressors a circadian rhythm could only be detected in the early morning contradicting, previous publications.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

Fingerprint

hyaluronic acid
Bed Rest
Hyaluronic Acid
Circadian Rhythm
circadian rhythm
food intake
Eating
Serum
physical activity
Meals
proteoglycans
Proteoglycans
diurnal variation
immunoassays
Immunoassay
exercise
ingestion
Exercise
Plasmas

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Circadian rhythm of hyaluronan in serum during bedrest and controlled food intake. / Roessler, A.; Kvas, E.; László, Z.; Hinghofer-Szalkay, H. G.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Roessler, A, Kvas, E, László, Z & Hinghofer-Szalkay, HG 1997, 'Circadian rhythm of hyaluronan in serum during bedrest and controlled food intake', FASEB Journal, vol. 11, no. 3.
Roessler, A. ; Kvas, E. ; László, Z. ; Hinghofer-Szalkay, H. G. / Circadian rhythm of hyaluronan in serum during bedrest and controlled food intake. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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