Circadian clocks and tumor biology: What is to learn from human skin biopsies?

Zsuzsanna Lengyel, Zita Battyáni, György Szekeres, Valér Csernus, András D. Nagy

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Some of the components of the circadian molecular clock have been shown to link directly to tumor suppression. Most studies on human tumorous biopsies with consistently down-regulated clock gene expression suggested a protective role for these genes against cancer formation. To highlight some limitations of this hypothesis we review these data in light of recent evidences from animal research, epidemiologic studies, and clinical data on skin tumors. We emphasize the role of circadian rhythmic orchestration in cellular metabolism with a potential in cancer development.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume188
Issue number1
DOIs
Publication statusPublished - Jul 1 2013

Keywords

  • Cancer
  • Circadian clock
  • Melanoma
  • Metabolism
  • Skin tumors

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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