Cigarette smoke elicits relaxation of renal arteries

Richárd Halmai, István András Szijártó, Eszter Fehér, Gábor Fésüs, Gergodouble acute A. Molnár, Pál Brasnyó, Ferenc Fülöp, Maik Gollasch, Akos Koller, István Wittmann

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Abstract

Eur J Clin Invest 2011; 41 (2): 195-202Background Epidemiological studies suggest that cigarette smoking - probably by eliciting hyperperfusion - increases glomerular filtration rate; thus, we hypothesized that cigarette smoke affects the vasomotor tone of renal arteries.Materials and methods Acute changes in the resistance index of a segmental renal artery were measured in healthy individuals during smoking. In addition, the effects of water-soluble components of cigarette smoke on the isometric tension of isolated rat renal arteries were investigated in various conditions.Results In humans, cigarette smoking transiently reduced the resistance index of the renal artery segments (83.25 ± 5.67% of the baseline, P < 0.05). In the experimental model, water-soluble components of cigarette smoke (wCS) - either nicotinic or nicotine-free - elicited dose-dependent relaxations of rat isolated renal arteries (1% solution of nicotinic wCS: 41.18 ± 14.86% relaxation, 5% nicotinic wCS: 79.28 ± 8.91% relaxation, 10% nicotinic wCS 90.3 ± 6.1% relaxation, P < 0.05), which were not affected by removal of the endothelium, or by the soluble guanylate cyclase inhibitor oxadiazolo-quinoxalin-1, or the non specific potassium channel blocker tetraethylammonium, or the KATP channel blocker glibenclamide. However, relaxations were reduced by catalase (1000 U mL-1 catalase + 5% nicotinic wCS: 49.71 ± 18.4%, P < 0.05) and enhanced by superoxide dismutase (200 U mL-1 SOD + 5% nicotinic wCS: 95.7 ± 2.3%, P < 0.05).Conclusions On the basis of these findings, we propose that cigarette smoking could contribute to the increased glomerular filtration rate observed in healthy smokers. In addition, cigarette smoke via hydrogen peroxide mediation reduces vasomotor tone of renal arteries, which could lead to hyperperfusion of kidneys.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalEuropean Journal of Clinical Investigation
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1 2011

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Keywords

  • Cigarette smoke
  • Hydrogen peroxide
  • Renal vasorelaxation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Halmai, R., András Szijártó, I., Fehér, E., Fésüs, G., Molnár, G. A. A., Brasnyó, P., Fülöp, F., Gollasch, M., Koller, A., & Wittmann, I. (2011). Cigarette smoke elicits relaxation of renal arteries. European Journal of Clinical Investigation, 41(2), 195-202. https://doi.org/10.1111/j.1365-2362.2010.02386.x