Chronological order of appearance of extraintestinal manifestations relative to the time of IBD diagnosis in the Swiss Inflammatory Bowel Disease Cohort

Swiss IBD Cohort Study Group

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD. Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Results: The data on 1249 patients were analyzed (49.8% female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8%] with Crohn's disease, 483 [38.7%] with ulcerative colitis, and 31 [2.5%] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3%). Of those, 63.4% presented with 1, 26.5% with 2, 4.9% with 3, 2.5% with 4, and 2.7% with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0%, aphthous stomatitis 21.6%, axial arthropathy/ankylosing spondylitis 16.4%, uveitis 13.7%, erythema nodosum 12.6%, primary sclerosing cholangitis 6.6%, pyoderma gangrenosum 4.9%, and psoriasis 2.7%. In 25.8% of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2% of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo). Conclusions: In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.

Original languageEnglish
Pages (from-to)1794-1800
Number of pages7
JournalInflammatory Bowel Diseases
Volume21
Issue number8
DOIs
Publication statusPublished - Apr 29 2015

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Inflammatory Bowel Diseases
Pyoderma Gangrenosum
Aphthous Stomatitis
Erythema Nodosum
Sclerosing Cholangitis
Joint Diseases
Ankylosing Spondylitis
Uveitis
Colitis
Ulcerative Colitis
Psoriasis
Crohn Disease
Arthritis
Cohort Studies
Physicians

Keywords

  • Arthritis
  • Extraintestinal manifestations
  • Inflammatory bowel disease
  • Uveitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Chronological order of appearance of extraintestinal manifestations relative to the time of IBD diagnosis in the Swiss Inflammatory Bowel Disease Cohort. / Swiss IBD Cohort Study Group.

In: Inflammatory Bowel Diseases, Vol. 21, No. 8, 29.04.2015, p. 1794-1800.

Research output: Contribution to journalArticle

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title = "Chronological order of appearance of extraintestinal manifestations relative to the time of IBD diagnosis in the Swiss Inflammatory Bowel Disease Cohort",
abstract = "Background: Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD. Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Results: The data on 1249 patients were analyzed (49.8{\%} female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8{\%}] with Crohn's disease, 483 [38.7{\%}] with ulcerative colitis, and 31 [2.5{\%}] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3{\%}). Of those, 63.4{\%} presented with 1, 26.5{\%} with 2, 4.9{\%} with 3, 2.5{\%} with 4, and 2.7{\%} with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0{\%}, aphthous stomatitis 21.6{\%}, axial arthropathy/ankylosing spondylitis 16.4{\%}, uveitis 13.7{\%}, erythema nodosum 12.6{\%}, primary sclerosing cholangitis 6.6{\%}, pyoderma gangrenosum 4.9{\%}, and psoriasis 2.7{\%}. In 25.8{\%} of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2{\%} of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo). Conclusions: In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.",
keywords = "Arthritis, Extraintestinal manifestations, Inflammatory bowel disease, Uveitis",
author = "{Swiss IBD Cohort Study Group} and Vavricka, {Stephan R.} and Gerhard Rogler and Claudine Gantenbein and Muriel Spoerri and Vavricka, {Mareike Prinz} and Navarini, {Alexander A.} and French, {Lars E.} and Ekaterina Safroneeva and Nicolas Fournier and Alex Straumann and Florian Froehlich and Michael Fried and Pierre Michetti and Frank Seibold and P. Lakatos and Laurent Peyrin-Biroulet and Schoepfer, {Alain M.}",
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AU - Vavricka, Stephan R.

AU - Rogler, Gerhard

AU - Gantenbein, Claudine

AU - Spoerri, Muriel

AU - Vavricka, Mareike Prinz

AU - Navarini, Alexander A.

AU - French, Lars E.

AU - Safroneeva, Ekaterina

AU - Fournier, Nicolas

AU - Straumann, Alex

AU - Froehlich, Florian

AU - Fried, Michael

AU - Michetti, Pierre

AU - Seibold, Frank

AU - Lakatos, P.

AU - Peyrin-Biroulet, Laurent

AU - Schoepfer, Alain M.

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N2 - Background: Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD. Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Results: The data on 1249 patients were analyzed (49.8% female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8%] with Crohn's disease, 483 [38.7%] with ulcerative colitis, and 31 [2.5%] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3%). Of those, 63.4% presented with 1, 26.5% with 2, 4.9% with 3, 2.5% with 4, and 2.7% with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0%, aphthous stomatitis 21.6%, axial arthropathy/ankylosing spondylitis 16.4%, uveitis 13.7%, erythema nodosum 12.6%, primary sclerosing cholangitis 6.6%, pyoderma gangrenosum 4.9%, and psoriasis 2.7%. In 25.8% of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2% of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo). Conclusions: In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.

AB - Background: Data evaluating the chronological order of appearance of extraintestinal manifestations (EIMs) relative to the time of inflammatory bowel disease (IBD) diagnosis is currently lacking. We aimed to assess the type, frequency, and chronological order of appearance of EIMs in patients with IBD. Methods: Data from the Swiss Inflammatory Bowel Disease Cohort Study were analyzed. Results: The data on 1249 patients were analyzed (49.8% female, median age: 40 [interquartile range, 30-51 yr], 735 [58.8%] with Crohn's disease, 483 [38.7%] with ulcerative colitis, and 31 [2.5%] with indeterminate colitis). A total of 366 patients presented with EIMs (29.3%). Of those, 63.4% presented with 1, 26.5% with 2, 4.9% with 3, 2.5% with 4, and 2.7% with 5 EIMs during their lifetime. Patients presented with the following diseases as first EIMs: peripheral arthritis 70.0%, aphthous stomatitis 21.6%, axial arthropathy/ankylosing spondylitis 16.4%, uveitis 13.7%, erythema nodosum 12.6%, primary sclerosing cholangitis 6.6%, pyoderma gangrenosum 4.9%, and psoriasis 2.7%. In 25.8% of cases, patients presented with their first EIM before IBD was diagnosed (median time 5 mo before IBD diagnosis: range, 0-25 mo), and in 74.2% of cases, the first EIM manifested itself after IBD diagnosis (median: 92 mo; range, 29-183 mo). Conclusions: In one quarter of patients with IBD, EIMs appeared before the time of IBD diagnosis. Occurrence of EIMs should prompt physicians to look for potential underlying IBD.

KW - Arthritis

KW - Extraintestinal manifestations

KW - Inflammatory bowel disease

KW - Uveitis

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