Chronic widespread pain is associated with worsening frailty in European men

Katie Fredrikawade, David M. Lee, John Mcbeth, Rathi Ravindrarajah, Evelien Gielen, Stephen R. Pye, Dirk Vanderschueren, Neil Pendleton, Joseph D. Finn, G. Bártfai, Felipe F. Casanueva, Gianni Forti, Aleksander Giwercman, Ilpo T. Huhtaniemi, Krzysztof Kula, Margus Punab, Frederick C W Wu, Terence W. O'neill

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty. Setting: longitudinal analysis within the European Male Ageing Study (EMAS). Participants: a total of 2,736 community-dwelling men aged 40-79. Methods: subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activity, smoking, alcohol consumption and depression were measured. Repeat assessments took place a median of 4.3 years later. A frailty index (FI) was used, with frail defined as an FI > 0.35. The association between CWP at baseline and the new occurrence of frailty was examined using logistic regression; the association between CWP at baseline and change in FI was examined using negative binomial regression. Results: at baseline, 218 (8.3%) men reported CWP. Of the 2,631 men who were defined as non-frail at baseline, 112 (4.3%) were frail at follow-up; their mean FI was 0.12 (SD 0.1) at baseline and 0.15 (SD 0.1) at follow-up, with a mean change of 0.03 (SD 0.08) P ≤ 0.001. Among men who were non-frail at baseline, those with CWP were significantly more likely to develop frailty. After adjustment for age and centre, compared with those with no pain, those with CWP at baseline had a 70% higher FI at follow-up; these associations remained significant after further adjustment for smoking, body mass index, depression, physical activity and FI at baseline. Conclusion: the presence of CWP is associated with an increased risk of frailty in older European men.

Original languageEnglish
Article numberafv170
Pages (from-to)268-274
Number of pages7
JournalAge and Ageing
Volume45
Issue number2
DOIs
Publication statusPublished - Mar 1 2016

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Chronic Pain
Smoking
Exercise
Depression
Manikins
Independent Living
Pain
Alcohol Drinking
Body Mass Index
Logistic Models

Keywords

  • Ageing
  • EMAS
  • Frailty
  • Male health
  • Pain

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Fredrikawade, K., Lee, D. M., Mcbeth, J., Ravindrarajah, R., Gielen, E., Pye, S. R., ... O'neill, T. W. (2016). Chronic widespread pain is associated with worsening frailty in European men. Age and Ageing, 45(2), 268-274. [afv170]. https://doi.org/10.1093/ageing/afv170

Chronic widespread pain is associated with worsening frailty in European men. / Fredrikawade, Katie; Lee, David M.; Mcbeth, John; Ravindrarajah, Rathi; Gielen, Evelien; Pye, Stephen R.; Vanderschueren, Dirk; Pendleton, Neil; Finn, Joseph D.; Bártfai, G.; Casanueva, Felipe F.; Forti, Gianni; Giwercman, Aleksander; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Punab, Margus; Wu, Frederick C W; O'neill, Terence W.

In: Age and Ageing, Vol. 45, No. 2, afv170, 01.03.2016, p. 268-274.

Research output: Contribution to journalArticle

Fredrikawade, K, Lee, DM, Mcbeth, J, Ravindrarajah, R, Gielen, E, Pye, SR, Vanderschueren, D, Pendleton, N, Finn, JD, Bártfai, G, Casanueva, FF, Forti, G, Giwercman, A, Huhtaniemi, IT, Kula, K, Punab, M, Wu, FCW & O'neill, TW 2016, 'Chronic widespread pain is associated with worsening frailty in European men', Age and Ageing, vol. 45, no. 2, afv170, pp. 268-274. https://doi.org/10.1093/ageing/afv170
Fredrikawade K, Lee DM, Mcbeth J, Ravindrarajah R, Gielen E, Pye SR et al. Chronic widespread pain is associated with worsening frailty in European men. Age and Ageing. 2016 Mar 1;45(2):268-274. afv170. https://doi.org/10.1093/ageing/afv170
Fredrikawade, Katie ; Lee, David M. ; Mcbeth, John ; Ravindrarajah, Rathi ; Gielen, Evelien ; Pye, Stephen R. ; Vanderschueren, Dirk ; Pendleton, Neil ; Finn, Joseph D. ; Bártfai, G. ; Casanueva, Felipe F. ; Forti, Gianni ; Giwercman, Aleksander ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Punab, Margus ; Wu, Frederick C W ; O'neill, Terence W. / Chronic widespread pain is associated with worsening frailty in European men. In: Age and Ageing. 2016 ; Vol. 45, No. 2. pp. 268-274.
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abstract = "Background: we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty. Setting: longitudinal analysis within the European Male Ageing Study (EMAS). Participants: a total of 2,736 community-dwelling men aged 40-79. Methods: subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activity, smoking, alcohol consumption and depression were measured. Repeat assessments took place a median of 4.3 years later. A frailty index (FI) was used, with frail defined as an FI > 0.35. The association between CWP at baseline and the new occurrence of frailty was examined using logistic regression; the association between CWP at baseline and change in FI was examined using negative binomial regression. Results: at baseline, 218 (8.3{\%}) men reported CWP. Of the 2,631 men who were defined as non-frail at baseline, 112 (4.3{\%}) were frail at follow-up; their mean FI was 0.12 (SD 0.1) at baseline and 0.15 (SD 0.1) at follow-up, with a mean change of 0.03 (SD 0.08) P ≤ 0.001. Among men who were non-frail at baseline, those with CWP were significantly more likely to develop frailty. After adjustment for age and centre, compared with those with no pain, those with CWP at baseline had a 70{\%} higher FI at follow-up; these associations remained significant after further adjustment for smoking, body mass index, depression, physical activity and FI at baseline. Conclusion: the presence of CWP is associated with an increased risk of frailty in older European men.",
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AU - Fredrikawade, Katie

AU - Lee, David M.

AU - Mcbeth, John

AU - Ravindrarajah, Rathi

AU - Gielen, Evelien

AU - Pye, Stephen R.

AU - Vanderschueren, Dirk

AU - Pendleton, Neil

AU - Finn, Joseph D.

AU - Bártfai, G.

AU - Casanueva, Felipe F.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Punab, Margus

AU - Wu, Frederick C W

AU - O'neill, Terence W.

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