Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice

P. Csermely, I. Pénzes, S. Toth

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Intracellular calcium concentration is a sensitive marker of the homeostasis of living cells, and its increase is an essential step of T lymphocyte activation. Changes in the environment provoke an adaptive stress-response of the organism. In our present work we have investigated the effect of chronic overcrowding on resting and lectin-stimulated cytoplasmic free calcium concentration of splenic T lymphocytes from young and aged CBA/CA mice (50 animals total). The animals were kept under 'normal' (68 cm2/animal) or 'overcrowded' (22 cm2/animal) conditions for 3 months. Young animals showed no change in resting and stimulated calcium after overcrowding. T cells from aged mice, however, displayed significantly smaller levels of both resting and lectin-stimulated intracellular calcium concentration (p

Original languageEnglish
Pages (from-to)976-979
Number of pages4
JournalExperientia
Volume51
Issue number9-10
DOIs
Publication statusPublished - Sep 1995

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Inbred CBA Mouse
T-cells
Animals
Calcium
T-Lymphocytes
Lectins
Lymphocyte Activation
Homeostasis
Chemical activation
Cells

Keywords

  • aging
  • animal housing
  • Calcium
  • lymphocyte activation
  • overcrowding
  • psychosocial stress
  • T lymphocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice. / Csermely, P.; Pénzes, I.; Toth, S.

In: Experientia, Vol. 51, No. 9-10, 09.1995, p. 976-979.

Research output: Contribution to journalArticle

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