Chronic nicotine-induced changes in dopaminergic system: Effect on behavioral response to dopamine agonist

Henry Sershen, Audrey Hashim, Laszlo Harsing, Abel Lajtha

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of chronic nicotine on dopamine-agonist-mediated locomotor activity response was measured in BALB/cBy and C57BL/6 mice. Mice were injected twice daily for 10 days with 1.2 mg/kg SC (-)-nicotine di-(+)tartrate. Subsequent locomotor activity response to apomorphine (1 mg/kg SC) was measured. Apomorphine induced hypomotility in both strains of mice, with the BALB/cBy mice showing a greater hypomotility compared to the C57BL/6 mice. The response to apomorphine was attenuated in both strains of mice that were treated previously with repeated injections of nicotine. The results suggest that chronic nicotine may induce changes in the dopaminergic system, which is reflected in altered behavioral response to a dopamine agonist.

Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume39
Issue number2
DOIs
Publication statusPublished - Jun 1991

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Keywords

  • Apomorphine
  • D2 autoreceptor
  • Dopaminergic system
  • Locomotor activity
  • Nicotine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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