A krónikus neutrophil leukaemiáról saját tapasztalataink alapján

Translated title of the contribution: Chronic neutrophillic leukemia: A long-term analysis of seven cases and review of the literature

Béla Telek, Péter Batár, M. Udvardy, László Rejto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chronic neutrophilic leukemia is an uncommon hematological entity. According to the WHO classification it is recognized as part of the family of myeloproliferative disorders. In the last 20 years seven patients have been diagnosed with chronic neutrophilic leukemia at our department. All but one had splenomegaly, two patients developed severe anaemia and in one case thrombocytosis was present at the time of diagnosis. White blood cell count ranged between 39 × 109/171 × 109/1 with 80% of neutrophils and striking myeloid hyperplasia were present in the bone marrow without evidence of any dysplasia resembling chronic myelocytic leukemia. Granulocyte alkaline phosphatase scores were increased except one case and both cytogenetics (Philadelphia chromosome) and molecular biologic analysis (bcr/abl) revealed no alteration of any. Four patients have been followed up. Three of them have been died due to progression of chronic neutrophilic leukemia. One patient, initially receiving hyroxyurea + interferon therapy and showing progression, developed complete hematological remission with an eight week imatinib mesylate (Glivec) treatment. Beside of their own experiences the authors review the current literature and discuss differential diagnostic and therapeutic challenges, as well.

Original languageHungarian
Pages (from-to)827-830
Number of pages4
JournalOrvosi Hetilap
Volume147
Issue number18
Publication statusPublished - May 7 2006

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Leukemia, Neutrophilic, Chronic
Leukemia
Thrombocytosis
Philadelphia Chromosome
Myeloproliferative Disorders
Splenomegaly
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukocyte Count
Granulocytes
Cytogenetics
Interferons
Hyperplasia
Alkaline Phosphatase
Anemia
Neutrophils
Therapeutics
Bone Marrow
Imatinib Mesylate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Telek, B., Batár, P., Udvardy, M., & Rejto, L. (2006). A krónikus neutrophil leukaemiáról saját tapasztalataink alapján. Orvosi Hetilap, 147(18), 827-830.

A krónikus neutrophil leukaemiáról saját tapasztalataink alapján. / Telek, Béla; Batár, Péter; Udvardy, M.; Rejto, László.

In: Orvosi Hetilap, Vol. 147, No. 18, 07.05.2006, p. 827-830.

Research output: Contribution to journalArticle

Telek, B, Batár, P, Udvardy, M & Rejto, L 2006, 'A krónikus neutrophil leukaemiáról saját tapasztalataink alapján', Orvosi Hetilap, vol. 147, no. 18, pp. 827-830.
Telek, Béla ; Batár, Péter ; Udvardy, M. ; Rejto, László. / A krónikus neutrophil leukaemiáról saját tapasztalataink alapján. In: Orvosi Hetilap. 2006 ; Vol. 147, No. 18. pp. 827-830.
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