A krónikus myeloid leukaemia korszerũ diagnosztikája és kezelése

Translated title of the contribution: Chronic myelogenous leukemia: Diagnosis and treatment

Judit Demeter, Anna Poros, Csaba Bödör, Laura Horváth, Tamás Masszi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Chronic myelogenous leukemia is a clonal myeloproliferative neoplasm caused by reciprocal translocation involving chromosomes 9 and 22 resulting in the expression of a constitutively activated BCR-ABL1 tyrosine kinase that leads to the malignant transformation of the hematopoietic stem cells. The condition was previously known as a relentlessly progressive disease, but the treatment was revolutionalized by the efficacy of tyrosine kinase inhibitors. Therapeutic success is thus currently determined by the depth of molecular response achieved on therapy. Multiple tyrosine kinase agents are available even for the first line treatment. This guideline summarizes current focal points of the treatment of chronic myelogenous leukemia specific to Hungary and provides definitions for optimal molecular responses in this condition.

Original languageHungarian
Pages (from-to)1459-1468
Number of pages10
JournalOrvosi hetilap
Volume157
Issue number37
DOIs
Publication statusPublished - Sep 2016

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ASJC Scopus subject areas

  • Medicine(all)

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