Koraszülöttek krónikus utóbetegségei

Translated title of the contribution: Chronic morbidities of premature newborns

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The most important chronic morbidities of premature newborns, deeply influencing quality of life, are retinopathy of prematurity, bronchopulmonary dysplasia, intraventricular hemorrhage and periventricular leukomalacia. Since the rate of premature birth has not decreased in recent years in Hungary, and treatments of these end stage disorders are extremely difficult, prevention gains tremendous significance. Effective prevention is based on detailed knowledge of the pathophysiological mechanisms of these special diseases having multifactorial nature sharing several common risk factors, and one is the pathological angiogenesis. This sensitive system is affected by several stress situations which are the consequences of prematurity leading to abnormal vascular growth. After birth, relative hyperoxia, compared to intrauterine life, and decreasing concentrations of vascular growth factors result in vascular injury, moreover, may cause vessel apoptosis. The consequence of this phenomenon is the activation of hypoxia responsible genes resulting in robust pathological neovascularization and organ damage during the later phase. Saving normal angiogenesis and inhibiting reactive neovascularization may lead to better quality of life in these premature infants.

Original languageHungarian
Pages (from-to)1498-1511
Number of pages14
JournalOrvosi Hetilap
Volume154
Issue number38
DOIs
Publication statusPublished - Sep 1 2013

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Pathologic Neovascularization
Quality of Life
Newborn Infant
Periventricular Leukomalacia
Morbidity
Bronchopulmonary Dysplasia
Retinopathy of Prematurity
Hyperoxia
Hungary
Vascular System Injuries
Premature Birth
Premature Infants
Blood Vessels
Intercellular Signaling Peptides and Proteins
Parturition
Apoptosis
Hemorrhage
Growth
Genes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Koraszülöttek krónikus utóbetegségei. / Balla, G.; Szabó, M.

In: Orvosi Hetilap, Vol. 154, No. 38, 01.09.2013, p. 1498-1511.

Research output: Contribution to journalArticle

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