Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats

Hajnalka Kompagne, G. Bárdos, G. Szénási, István Gacsályi, L. Hársing, György Lévay

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social avoidance and increased grooming, but acted as if reducing anxiety in the plus-maze. Sucrose preference and social avoidance, but not other measures of the behaviour, showed significant correlation. We conclude that CMS-induced depression-like behaviour is associated with social avoidance, a seemingly anxiety-related measure, but not with other anxiety-like traits in rats.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalBehavioural Brain Research
Volume193
Issue number2
DOIs
Publication statusPublished - Nov 21 2008

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Anxiety
Sucrose
Grooming
Depression

Keywords

  • Anhedonia
  • Anxiety-related behaviour
  • Chronic mild stress
  • Depression
  • Rat
  • Social avoidance

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. / Kompagne, Hajnalka; Bárdos, G.; Szénási, G.; Gacsályi, István; Hársing, L.; Lévay, György.

In: Behavioural Brain Research, Vol. 193, No. 2, 21.11.2008, p. 311-314.

Research output: Contribution to journalArticle

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