Chronic infections and genetic factors in the development of ischemic stroke

Zoltan Kis, Katalin Sas, Zsofia Gyulai, Balint Treso, Fruzsina Petrovay, Beatrix Kapusinszky, Marta Csire, Valeria Endresz, Katalin Burian, Yvette Mandi, Laszlo Vecsei, Eva Gonczol

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The aim of this study was to examine whether chronic infections and genetic factors of the host play roles in the pathophysiology of acute noncardioembolic ischemic stroke. Blood samples from 59 subjects with ischemic stroke and 52 control patients were investigated by nested PCR for the presence of C. pneumoniae DNA, HCMV DNA and enterovirus RNA, by ELISA for the levels of antibodies to C. pneumoniae, HCMV, HSV, HHV-6, EBV and the inflammatory chemokine IL-8, and by PCR for promoter polymorphism of the IL-8 and CD14 host genes. Associations of stroke with the HCMV IgG and HSV-1 IgA antibody levels were observed. No association of stroke was detect-ed with the presence of C. pneumoniae, HCMV or enterovirus nucleic acids in the peripheral blood, C. pneumoniae IgM, IgG and IgA, the HSV IgG, the EBV IgG, or HHV-6 IgG antibody levels, the pathogen burden, the IL-8 or CD14 promoter polymorphisms, or with the serum levels of IL-8 in the overall study population. These results are consistent with the hypothesis that certain pathogens are involved in the development of ischemic stroke.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalNew Microbiologica
Volume30
Issue number3
Publication statusPublished - Jul 1 2007

Keywords

  • CD14
  • HCMV IgG
  • HSV-1 IgA
  • IL-8
  • Ischemic stroke
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)

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