Chronic ethanol ingestion decreases vasopressin mRNA in hypothalamic and extrahypothalamic nuclei of mouse brain

K. Gulya, Jitendra R. Dave, Paula L. Hoffman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Endogenous arginine vasopressin was previously shown to modulate the rate of loss of functional (CNS) tolerance to ethanol, suggesting that chronic ethanol ingestion might after vasopressin synthesis and/or release. Since extrahypothalamic vasopressin is believed to be involved in the CNS effects of the peptide, we determined the effect of ethanol on vasopressin mRNA in the bed nucleus of the stria terminalis (BST), as well as in several hypothalamic nuclei. Chronic ethanol ingestion, that produced functional tolerance and physical dependence in mice, resulted in decreased vasopressin mRNA levels in all areas examined. In contrast, as expected, dehydration resulted in increases in vasopressin mRNA in the BST and in all hypothalamic nuclei except the suprachiasmatic nucleus. In the BST, both ethanol ingestion and dehydration affected cells in the central region of the nucleus, while cells in the caudal portion were only affected by ethanol treatment. The results indicate that chronic ethanol ingestion generally reduces the synthesis of vasopressin, and that increased vasopressin synthesis is not necessary in order for the peptide to affect ethanol tolerance.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalBrain Research
Volume557
Issue number1-2
DOIs
Publication statusPublished - Aug 23 1991

Fingerprint

Vasopressins
Ethanol
Eating
Messenger RNA
Brain
Septal Nuclei
Dehydration
Peptides
Suprachiasmatic Nucleus
Arginine Vasopressin
Cell Nucleus

Keywords

  • Chronic ethanol treatment
  • effect of ethanol
  • Extrahypothalamic vasopressin mRNA
  • Hypothalamic vasopressin mRNA
  • In situ hybridization
  • Vasopressin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chronic ethanol ingestion decreases vasopressin mRNA in hypothalamic and extrahypothalamic nuclei of mouse brain. / Gulya, K.; Dave, Jitendra R.; Hoffman, Paula L.

In: Brain Research, Vol. 557, No. 1-2, 23.08.1991, p. 129-135.

Research output: Contribution to journalArticle

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