Chronic bullous dermatosis of childhood

S. Kárpáti, E. Torok, Z. Vajda, I. Répay, I. Kósnai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A study of 16 patients with chronic bullous dermatosis of childhood (CBDC) is reported. They were followed up for 0.5 to 4.5 years. Histological and immunofluorescent (IF) study of the skin and local provocation of skin lesions by Trafuril test were carried out in every case, intestinal biopsy in twelve cases. Four patients were found to have IgG, and three IgA, along the skin basement membrane. In nine patients, no immunoglobulins were detectable; these IF negative cases seemed to be pseudonegative. Repeated biopsy and immunoelectronmicroscopic study of the skin may be helpful. In the three patient groups classified on the basis of skin IF studies, there was no difference in the clinical and histological picture, in reaction to Trafuril test and in the result of treatment. The small intestinal mucosa was abnormal in three of twelve patients. A gluten-free diet introduced in two patients had no effect on the course of the disease. CBDC with negative or positive IF, juvenile pemphigoid and IgA linear dermatosis seem to be a common clinical entity, different in severity and with individual variations. The condition is not identical with dermatitis herpetiformis Duhring.

Original languageEnglish
Pages (from-to)331-339
Number of pages9
JournalActa Paediatrica Academiae Scientiarum Hungaricae
Volume22
Issue number4
Publication statusPublished - 1981

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Vesiculobullous Skin Diseases
Skin
Linear IgA Bullous Dermatosis
Dermatitis Herpetiformis
Biopsy
Gluten-Free Diet
Bullous Pemphigoid
Intestinal Mucosa
Basement Membrane
Immunoglobulin A
Immunoglobulins
Immunoglobulin G

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kárpáti, S., Torok, E., Vajda, Z., Répay, I., & Kósnai, I. (1981). Chronic bullous dermatosis of childhood. Acta Paediatrica Academiae Scientiarum Hungaricae, 22(4), 331-339.

Chronic bullous dermatosis of childhood. / Kárpáti, S.; Torok, E.; Vajda, Z.; Répay, I.; Kósnai, I.

In: Acta Paediatrica Academiae Scientiarum Hungaricae, Vol. 22, No. 4, 1981, p. 331-339.

Research output: Contribution to journalArticle

Kárpáti, S, Torok, E, Vajda, Z, Répay, I & Kósnai, I 1981, 'Chronic bullous dermatosis of childhood', Acta Paediatrica Academiae Scientiarum Hungaricae, vol. 22, no. 4, pp. 331-339.
Kárpáti, S. ; Torok, E. ; Vajda, Z. ; Répay, I. ; Kósnai, I. / Chronic bullous dermatosis of childhood. In: Acta Paediatrica Academiae Scientiarum Hungaricae. 1981 ; Vol. 22, No. 4. pp. 331-339.
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