Chronic administration of quercetin induces biomechanical and pharmacological remodeling in the rat coronary arteries

A. Monori-Kiss, F. Kiss, J. M. Restifo, E. Monos, G. Nádasy

Research output: Contribution to journalArticle

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Abstract

Acute dilation brought about by the dietary flavonoid quercetin in coronary arterioles has been described earlier, but no information is available on its chronic effects. Male Wistar rats (body weight about 190 g) were divided to two groups: the quercetin-treated group (n=22) had quercetin supplementation of approximately 30 mg/kg/day, whereas the control group (n=20) had none. After eight weeks of treatment, intramural coronary arterioles with identical passive diameters (178±14 μm and 171±9 μm) were prepared and their biomechanics and pharmacological reactivities were tested using pressure arteriography ex vivo. The spontaneous tone of quercetin-treated arteries was higher (16.5±1.9 % vs. 12.9±0.9 %), which resulted in a reduced lumen size (144±9 μm vs. 167±12 μm), thicker vascular wall (22.6±1.8 μm vs. 17.4±1.6 μm) and decreased tangential wall stress (16.8±1.1 kPa vs. 20.5±1.6 kPa) in supplemented animals (in spontaneous tone at 50 mm Hg, p<0.01 in all these comparisons). Elevated basal NO release resulted in increased endothelial dilation in quercetin-treated animals, especially at higher intraluminal pressures (10.8±2.5 % vs. 5.7±1.3 % at 70 mm Hg, p<0.01). We found remodeling of the geometry of coronary arterioles to ensure higher dilatory reserve and nitrogen monoxide production, as well as lowered elastic stress of the vessel wall.

Original languageEnglish
Pages (from-to)591-599
Number of pages9
JournalPhysiological Research
Volume66
Issue number4
Publication statusPublished - Jan 1 2017

Fingerprint

Quercetin
Coronary Vessels
Pharmacology
Arterioles
Dilatation
Pressure
Biomechanical Phenomena
Flavonoids
Blood Vessels
Wistar Rats
Angiography
Nitric Oxide
Arteries
Body Weight
Control Groups

Keywords

  • Arterioles
  • Coronary circulation
  • Endothelial nitric oxide synthase
  • Quercetin
  • Vascular remodeling

ASJC Scopus subject areas

  • Physiology

Cite this

Chronic administration of quercetin induces biomechanical and pharmacological remodeling in the rat coronary arteries. / Monori-Kiss, A.; Kiss, F.; Restifo, J. M.; Monos, E.; Nádasy, G.

In: Physiological Research, Vol. 66, No. 4, 01.01.2017, p. 591-599.

Research output: Contribution to journalArticle

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