On account of the difficulties to extrapolate data of animal experiments efforts are being made to elaborate suitable methods for human investigation. Chromosome analyses of peripheral blood culture in suicide cases offer such possibilities: The patients are seriously intoxicated. Chemicals, approximate dose and time of intoxication are known. Self-control study can be made because chromosome aberrations do not develop within 12 h of intoxication thus they can represent the 'O-values', between 36-72 h the 'intoxication-values' and after 3-6 months the 'recovery-values' can be determined in alive cases. Extra examinations are not made therefore ethical problems do not emerge. Some drugs and chemicals are studied blind in suicide cases.
|Pages (from-to)||No. 49|
|Publication status||Published - Jan 1 1978|
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis