Chromosome studies in twelve patients with retinoblastoma

E. Czeizel, L. Csósz, Judit Gárdonyi, L. Remenár, P. Ruziscka

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Chromosome studies in 12 children suffering from retinoblastoma revealed a significantly elevated frequency of aneuploids, chromatid-type aberrations and stable abnormalities of the chromosome type. A similar increase in the occurrence of chromosome abnormalities was found in cases of retinoblastoma not exposed to therapeutic irradiation. These findings indicate that an increased fragility of the chromosomes must be assumed in patients with retinoblastoma, which may be associated with a general increase in the predisposition to develop tumors.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalHuman Genetics
Volume22
Issue number2
DOIs
Publication statusPublished - Jun 1974

Fingerprint

Retinoblastoma
Chromosomes
Chromosome Aberrations
Chromosome Fragility
Chromatids
Aneuploidy
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

Cite this

Czeizel, E., Csósz, L., Gárdonyi, J., Remenár, L., & Ruziscka, P. (1974). Chromosome studies in twelve patients with retinoblastoma. Human Genetics, 22(2), 159-166. https://doi.org/10.1007/BF00278455

Chromosome studies in twelve patients with retinoblastoma. / Czeizel, E.; Csósz, L.; Gárdonyi, Judit; Remenár, L.; Ruziscka, P.

In: Human Genetics, Vol. 22, No. 2, 06.1974, p. 159-166.

Research output: Contribution to journalArticle

Czeizel, E, Csósz, L, Gárdonyi, J, Remenár, L & Ruziscka, P 1974, 'Chromosome studies in twelve patients with retinoblastoma', Human Genetics, vol. 22, no. 2, pp. 159-166. https://doi.org/10.1007/BF00278455
Czeizel E, Csósz L, Gárdonyi J, Remenár L, Ruziscka P. Chromosome studies in twelve patients with retinoblastoma. Human Genetics. 1974 Jun;22(2):159-166. https://doi.org/10.1007/BF00278455
Czeizel, E. ; Csósz, L. ; Gárdonyi, Judit ; Remenár, L. ; Ruziscka, P. / Chromosome studies in twelve patients with retinoblastoma. In: Human Genetics. 1974 ; Vol. 22, No. 2. pp. 159-166.
@article{1e8f20365eb240cd8f35c463bb416979,
title = "Chromosome studies in twelve patients with retinoblastoma",
abstract = "Chromosome studies in 12 children suffering from retinoblastoma revealed a significantly elevated frequency of aneuploids, chromatid-type aberrations and stable abnormalities of the chromosome type. A similar increase in the occurrence of chromosome abnormalities was found in cases of retinoblastoma not exposed to therapeutic irradiation. These findings indicate that an increased fragility of the chromosomes must be assumed in patients with retinoblastoma, which may be associated with a general increase in the predisposition to develop tumors.",
author = "E. Czeizel and L. Cs{\'o}sz and Judit G{\'a}rdonyi and L. Remen{\'a}r and P. Ruziscka",
year = "1974",
month = "6",
doi = "10.1007/BF00278455",
language = "English",
volume = "22",
pages = "159--166",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Chromosome studies in twelve patients with retinoblastoma

AU - Czeizel, E.

AU - Csósz, L.

AU - Gárdonyi, Judit

AU - Remenár, L.

AU - Ruziscka, P.

PY - 1974/6

Y1 - 1974/6

N2 - Chromosome studies in 12 children suffering from retinoblastoma revealed a significantly elevated frequency of aneuploids, chromatid-type aberrations and stable abnormalities of the chromosome type. A similar increase in the occurrence of chromosome abnormalities was found in cases of retinoblastoma not exposed to therapeutic irradiation. These findings indicate that an increased fragility of the chromosomes must be assumed in patients with retinoblastoma, which may be associated with a general increase in the predisposition to develop tumors.

AB - Chromosome studies in 12 children suffering from retinoblastoma revealed a significantly elevated frequency of aneuploids, chromatid-type aberrations and stable abnormalities of the chromosome type. A similar increase in the occurrence of chromosome abnormalities was found in cases of retinoblastoma not exposed to therapeutic irradiation. These findings indicate that an increased fragility of the chromosomes must be assumed in patients with retinoblastoma, which may be associated with a general increase in the predisposition to develop tumors.

UR - http://www.scopus.com/inward/record.url?scp=0016184206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016184206&partnerID=8YFLogxK

U2 - 10.1007/BF00278455

DO - 10.1007/BF00278455

M3 - Article

C2 - 4843909

AN - SCOPUS:0016184206

VL - 22

SP - 159

EP - 166

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 2

ER -