Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication

van Bao Trinh van Bao, Ildikó Szabó, Péter Ruzicska, Andrew Czeizel

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Abstract

The mutagenicity of several insecticides (Fosfotion (Malathion), Ditriphon-50 (Trichlorfon), Wofatox (Methyl-parathion), Phosdrin (Mevinphos), Bi 58 (Dimethoate), Basudin E (Diazinon), Nuvan (Dichlorvos)) containing organic phosphoric acid esters was studied in the lymphocyte cultures of patients suffering intoxication as a result of either attempting to commit suicide or exposure during work due to violation of safety measures or inexperience. From each patient-except those who died in the acute period-three blood samples were taken: immediately (3 to 6 days) after exposure and about 30 and 180 days after intoxication. The results of the chromosome studies were compared to the seriousness of the intoxication and to the individual insecticides. A temporary, but significant increase was found in the frequency of chromatid breaks and stable chromosome-type aberrations in acutely intoxicated persons. The results obtained strongly suggest that the organic phosphoric acid esters studied exert direct mutagenic effects on the chromosomes.

Original languageEnglish
Pages (from-to)33-57
Number of pages25
JournalHuman genetics
Volume24
Issue number1
DOIs
Publication statusPublished - Mar 1 1974

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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