Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication

van Bao Trinh van Bao, Ildikó Szabó, Péter Ruzicska, E. Czeizel

Research output: Contribution to journalArticle

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Abstract

The mutagenicity of several insecticides (Fosfotion (Malathion), Ditriphon-50 (Trichlorfon), Wofatox (Methyl-parathion), Phosdrin (Mevinphos), Bi 58 (Dimethoate), Basudin E (Diazinon), Nuvan (Dichlorvos)) containing organic phosphoric acid esters was studied in the lymphocyte cultures of patients suffering intoxication as a result of either attempting to commit suicide or exposure during work due to violation of safety measures or inexperience. From each patient-except those who died in the acute period-three blood samples were taken: immediately (3 to 6 days) after exposure and about 30 and 180 days after intoxication. The results of the chromosome studies were compared to the seriousness of the intoxication and to the individual insecticides. A temporary, but significant increase was found in the frequency of chromatid breaks and stable chromosome-type aberrations in acutely intoxicated persons. The results obtained strongly suggest that the organic phosphoric acid esters studied exert direct mutagenic effects on the chromosomes.

Original languageEnglish
Pages (from-to)33-57
Number of pages25
JournalHuman Genetics
Volume24
Issue number1
DOIs
Publication statusPublished - Mar 1974

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Mevinphos
Dimethoate
Methyl Parathion
Organophosphates
Insecticides
Chromosome Aberrations
Chromosomes
Trichlorfon
Dichlorvos
Diazinon
Malathion
Chromatids
Suicide
Lymphocytes
Safety

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication. / Trinh van Bao, van Bao; Szabó, Ildikó; Ruzicska, Péter; Czeizel, E.

In: Human Genetics, Vol. 24, No. 1, 03.1974, p. 33-57.

Research output: Contribution to journalArticle

Trinh van Bao, van Bao ; Szabó, Ildikó ; Ruzicska, Péter ; Czeizel, E. / Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication. In: Human Genetics. 1974 ; Vol. 24, No. 1. pp. 33-57.
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