Chromatographic techniques in studies of the calcium channels and of calcium antagonists in physiological cells

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Abstract

In the past decade, the primary structure of L-type voltage-dependent calcium channels was elucidated and the calcium-antagonist binding sites localized. The results were achieved with the help of biochemical, molecular genetic, and electrophysiological methods combined with numerous types of chromatography. An important objective of research on calcium channels has focused on the complex question of where the calcium antagonists interact with the binding sites, and how they block the movement of calcium ions. Some definite answers have been given concerning the high-affinity binding sites of calcium channels. Approaches to learning the structure of calcium channels and of localizing calcium-antagonist binding sites have utilized a variety of Chromatographic methods.

Original languageEnglish
Pages (from-to)442-449
Number of pages8
JournalTrAC - Trends in Analytical Chemistry
Volume14
Issue number9
DOIs
Publication statusPublished - 1995

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Calcium Channels
calcium
Binding Sites
Calcium
L-Type Calcium Channels
Chromatography
Ions
chromatography
learning
ion

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

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AB - In the past decade, the primary structure of L-type voltage-dependent calcium channels was elucidated and the calcium-antagonist binding sites localized. The results were achieved with the help of biochemical, molecular genetic, and electrophysiological methods combined with numerous types of chromatography. An important objective of research on calcium channels has focused on the complex question of where the calcium antagonists interact with the binding sites, and how they block the movement of calcium ions. Some definite answers have been given concerning the high-affinity binding sites of calcium channels. Approaches to learning the structure of calcium channels and of localizing calcium-antagonist binding sites have utilized a variety of Chromatographic methods.

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