Chromatographic behavior of silica-polymer composite molecularly imprinted materials

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15 Citations (Scopus)

Abstract

Molecularly imprinted polymers (MIP) have recently been prepared inside the pores of silica based HPLC packing materials. Detailed physical and chromatographic characterization of such a silica-MIP composite material is presented. The chromatographic peak shape obtained with the uniformly sized spherical silica-MIP composite is mainly determined by the nonlinear adsorption isotherm. Comparison of the composite with the conventional sieved and grinded bulk MIP is therefore based on the nonlinear isotherm and not on retention factors and plate numbers.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalJournal of Chromatography A
Volume1100
Issue number1
DOIs
Publication statusPublished - Dec 23 2005

Keywords

  • Composite
  • HPLC
  • Imprinted polymer
  • Nonlinear

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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