Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain

Markus Morawski, A. Alpár, Gert Brückner, Anja Fiedler, Carsten Jäger, Georgina Gati, Jens T. Stieler, Thomas Arendt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A specialised form of extracellular matrix consisting of large aggregating chondroitin sulphate proteoglycans connected to hyaluronan and tenascins, as main components, is termed perineuronal nets. These perineuronal nets surround subpopulations of neurons in many vertebrates including man. In this study we investigated the distribution and the postnatal development of perineuronal nets in the brain of the domestic chicken using immunohistochemical, lectin-histochemical and biochemical methods. Perineuronal nets could be identified very early, already on the first postnatal day throughout various regions and nuclei in chicken fore- and midbrains, most expressively in nidopallium, hyperpallium, lateral striatum, globus pallidus and mesopallium. These mostly delicate, scanty structures around the cell bodies of neurons thicken and complete during the first 2 weeks, however, differ in shape and clearness of contours from the mature form of perineuronal nets found in the adult, 3 year old animals. Perineuronal nets frequently co-localized with the potassium channel subunit Kv3.1b characteristic for fast spiking neurons but remained unrevealed around cholinergic or monoaminergic neurons. The early appearance of perineuronal nets in the precocial birds' brain is probably due to the rapid establishment of neuronal morphology and function which is required for the immediate functional and behavioural performance of chicken.

Original languageEnglish
Pages (from-to)10-23
Number of pages14
JournalBrain Research
Volume1275
DOIs
Publication statusPublished - Jun 12 2009

Fingerprint

Chondroitin Sulfate Proteoglycans
Extracellular Matrix
Chickens
Neurons
Brain
Tenascin
Globus Pallidus
Potassium Channels
Hyaluronic Acid
Prosencephalon
Mesencephalon
Lectins
Cholinergic Agents
Birds
Vertebrates

Keywords

  • Aggrecan
  • Chondroitin sulphate proteoglycan
  • Lectin
  • Link protein
  • Perineuronal net

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain. / Morawski, Markus; Alpár, A.; Brückner, Gert; Fiedler, Anja; Jäger, Carsten; Gati, Georgina; Stieler, Jens T.; Arendt, Thomas.

In: Brain Research, Vol. 1275, 12.06.2009, p. 10-23.

Research output: Contribution to journalArticle

Morawski, M, Alpár, A, Brückner, G, Fiedler, A, Jäger, C, Gati, G, Stieler, JT & Arendt, T 2009, 'Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain', Brain Research, vol. 1275, pp. 10-23. https://doi.org/10.1016/j.brainres.2009.02.046
Morawski, Markus ; Alpár, A. ; Brückner, Gert ; Fiedler, Anja ; Jäger, Carsten ; Gati, Georgina ; Stieler, Jens T. ; Arendt, Thomas. / Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain. In: Brain Research. 2009 ; Vol. 1275. pp. 10-23.
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