Cholinotoxic Effects of Aluminum in Rat Brain

K. Gulya, Z. Rakonczay, P. Kása

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Abstract: The in vivo and in vitro effects of A1 on the cholinergic system of rat brain were studied. The amount of A1 accumulated after the chronic, intraperitoneal administration of aluminum gluconate (Al‐G) or AlCl3, both at a dose of 1 mg/ml/100 g of body weight, increased in the frontal and parietal cortices, the hippocampus, and the striatum. Significantly decreased choline acetyltransferase activities after chronic Al treatment were measured in the parietal cortex, the hippocampus, and the striatum, but not in the frontal cortex. The acetylcholinesterase activity was not changed significantly in any brain area investigated. Both Al‐G and AlCl3 administrations resulted in a general decrease (to 40–70% of the control values) in the specific l‐[3H]nicotine binding, involving all brain areas studied. The specific (–)‐[3H]quinuclidinyl benzilate binding was reduced (to 40–60% of the control values) only after 25 days of Al treatment. Al‐G and AlCl3 were equivalent in eliciting these reductions. In vitro studies revealed different alterations of the cholinergic system in response to Al treatment. No changes were observed either in choline acetyltransferase activity or in cholinergic receptor bindings. Both Al‐G and Al2(SO4)3 treatments, however, exhibited a biphasic effect on the acetylcholinesterase activity. At low Al concentrations (10–8–10–6M), the activity was slightly increased, whereas at higher concentrations (10–6–10–4M), it was inhibited by a maximum of 25% as compared to the controls. Thus, these cholinotoxic effects are probably due not to a direct interaction between the metal and the cholinergic marker proteins, but rather to a manifestation and consequence of its neurodegenerative effects.

Original languageEnglish
Pages (from-to)1020-1026
Number of pages7
JournalJournal of neurochemistry
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 1990

Keywords

  • Aluminum
  • Cholinergic system
  • Cholinotoxicity

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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