Cholinotoxic effects of β-amyloid(1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis

Tibor Harkany, Zsolt Lengyel, Katalin Soós, Botond Penke, Paul G.M. Luiten, Karoly Gulya

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

β-Amyloid(1-42) peptide (βAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of βAP in an in vivo animal model.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalBrain research
Volume695
Issue number1
DOIs
Publication statusPublished - Oct 9 1995

Keywords

  • Cholinergic system
  • Cholinotoxicity
  • Frontal cortex
  • Nucleus basalis magnocellularis
  • β-Amyloid peptide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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