Cholinergic afferents to gonadotropin-releasing hormone neurons of the rat

Gergely F. Turi, Z. Liposits, E. Hrabovszky

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone-synthesizing neurons represent the final common pathway in the hypothalamic regulation of reproduction and their secretory activity is influenced by a variety of neurotransmitters and neuromodulators acting centrally in synaptic afferents to gonadotropin-releasing hormone neurons. The present study examined the anatomical relationship of cholinergic neuronal pathways and gonadotropin-releasing hormone neurons of the preoptic area. The immunocytochemical detection of choline acetyltransferase or vesicular acetylcholine transporter revealed a fine network of cholinergic fibers in this region. At the light microscopic level, the cholinergic axons formed appositions to the gonadotropin-releasing hormone immunoreactive cell bodies and dendrites. Results of electron microscopic studies confirmed the absence of glial interpositions in many of these neuronal contacts. Classical cholinergic synapses, which belonged to the asymmetric category, were only observed rarely on gonadotropin-releasing hormone neurons. The lack of synaptic density in most contacts corroborates previous observations on the cholinergic system elsewhere in the brain. Further, it suggests a dominantly non-synaptic route also in this cholinergic neuronal communication. This study provides direct neuromorphological evidence for the involvement of the cholinergic system in the afferent neuronal regulation of gonadotropin-releasing hormone neurons. The sources of cholinergic afferents and the receptorial mechanisms underlying this interaction will require further clarification.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalNeurochemistry International
Volume52
Issue number4-5
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Gonadotropin-Releasing Hormone
Cholinergic Agents
Neurons
Neurotransmitter Agents
Vesicular Acetylcholine Transport Proteins
Cholinergic Fibers
Preoptic Area
Choline O-Acetyltransferase
Dendrites
Neuroglia
Synapses
Reproduction
Axons
Electrons
Light
Brain

Keywords

  • Acetylcholine
  • ChAT
  • Luteinizing hormone-releasing hormone
  • Preoptic area
  • Reproduction
  • VAChT

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Cholinergic afferents to gonadotropin-releasing hormone neurons of the rat. / Turi, Gergely F.; Liposits, Z.; Hrabovszky, E.

In: Neurochemistry International, Vol. 52, No. 4-5, 03.2008, p. 723-728.

Research output: Contribution to journalArticle

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