Choleric potencies of some bile acids and their effect on biliary excretion of eosine in the rat

E. Fischer, A. Barth, W. Klinger, Z. Gregus, F. Varga

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Abstract

The effects of bile acids on bile flow and biliary excretion (80 mg/kg i.v.) has been investigated in anaesthetized (urethane 1.2 g/kg i.p.), bile duct-cannulated female Sprague-Dawley rats weighing 180-220 g. The biliary flow was significantly enhanced by cholic acid, glycocholic acid, taurocholic acid, deoxycholic acid, chenodeoxycholic acid and dehydrocholic acid (each in a dose of 100 mg/kg i.v.). However, it was definitely decreased by lithocholic acid (10 mg/kg i.v.). The biliary excretion of eosine was increased by cholic acid and dehydrocholic acid, whereas it was decreased by chenodeoxycholic acid and lithocholic acid. Deoxycholic acid, glycocholic acid and taurocholic acid had no effect on the biliary excretion rate of eosine. These results suggest that no parallelism exists between the choleretic effect of bile acids and their influence on the biliary excretion of eosine.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalActa Biologica et Medica Germanica
Volume39
Issue number6
Publication statusPublished - 1980

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Eosine Yellowish-(YS)
Bile Acids and Salts
Dehydrocholic Acid
Glycocholic Acid
Lithocholic Acid
Chenodeoxycholic Acid
Cholic Acid
Taurocholic Acid
Deoxycholic Acid
Cholagogues and Choleretics
Urethane
Bile Ducts
Bile
Sprague Dawley Rats
Hepatobiliary Elimination

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Choleric potencies of some bile acids and their effect on biliary excretion of eosine in the rat. / Fischer, E.; Barth, A.; Klinger, W.; Gregus, Z.; Varga, F.

In: Acta Biologica et Medica Germanica, Vol. 39, No. 6, 1980, p. 711-715.

Research output: Contribution to journalArticle

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