Cholecystokinin-like bioactivity in rat cerebral cortex

A. Varró, Z. Berger, F. Hajnal, J. Lonovics, A. Pap

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cholecystokinin (CCK)-like bioactivity was studied in extracts of rat cerebral cortex by three different bioassays. Positive results were obtained by all procedures used. A fairly good quantitative correlation was found when testing the same extracts by two of the methods. A considerable amount of CCK-like activity was demonstrated in the various subcellular fractions (synaptic membranes, synaptic vesicles, and synaptic fragments) corresponding to synaptic structures. The results are in accordance with the findings of several authors who demonstrated CCK-like immunoreactivity in the brain, especially in the cortex. The use of three different bioassays in three species (rabbit, rat, dog) seems to prove that some bioactive molecular form of CCK exists in the brain, mainly in the cortical area. The finding that subcellular elements of the synaptic structures contain relatively high concentrations of CCK raises the question of the possible role of CCK in the neuronal transmission.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalScandinavian Journal of Gastroenterology
Volume16
Issue number5
DOIs
Publication statusPublished - 1981

Fingerprint

Cholecystokinin
Cerebral Cortex
Biological Assay
Synaptic Membranes
Subcellular Fractions
Synaptic Vesicles
Brain
Dogs
Rabbits

Keywords

  • Bioassays of CCK
  • Cholecystokinin-cerebral cortex
  • Synaptic regions

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cholecystokinin-like bioactivity in rat cerebral cortex. / Varró, A.; Berger, Z.; Hajnal, F.; Lonovics, J.; Pap, A.

In: Scandinavian Journal of Gastroenterology, Vol. 16, No. 5, 1981, p. 611-614.

Research output: Contribution to journalArticle

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