Cholecystokinin interferes with the thermoregulatory effect of exogenous and endogenous opioids

L. Kapás, G. Benedek, B. Penke

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Intraperitoneal (ip) injection of cholecystokinin octapeptide sulfate ester (CCK; 5, 10 and 50 μg/kg) reduced the hypothermic response to 8 mg/kg and 32 mg/kg systemic morphine in restrained and freely moving rats, respectively. The hyperthermia elicited by a subcutaneous (sc) injection of 8 mg/kg morphine to freely moving rats was not diminished by CCK pretreatment. CCK (5 μg/kp ip) completely prevented the restraint stress-induced hyperthermia. Naloxone (1 mg/gk sc) was effective in antagonizing both the hyperthermic and the hypothermic effects of morphine and the stress-induced emotional hyperthermia. These results support the hypothesis that CCK may contribute to regulation of the endogenous opioid system.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalNeuropeptides
Volume14
Issue number2
DOIs
Publication statusPublished - 1989

Fingerprint

Cholecystokinin
Morphine
Opioid Analgesics
Induced Hyperthermia
Rats
Sincalide
Subcutaneous Injections
Naloxone
Intraperitoneal Injections
Psychological Stress
Sulfates
Esters
Fever
cholecystokinin pentapeptide

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Cholecystokinin interferes with the thermoregulatory effect of exogenous and endogenous opioids. / Kapás, L.; Benedek, G.; Penke, B.

In: Neuropeptides, Vol. 14, No. 2, 1989, p. 85-92.

Research output: Contribution to journalArticle

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