Cholecystokinin in the hypothalamo-hypophyseal system

M. Palkóvits, József Z. Kiss, Margery C. Beinfeld, Michael J. Brownstein

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Immunohistochemical studies on cholecystokinin-like (CCK-ir) substances in colchicine-pretreated rats demonstrated that in addition to CCK-ir cells in the magnocellular portion of the paraventricular nucleus, CCK-ir cells are also present among the parvocellular neurons. Radioimmunoassay of CCK after paraventricular lesions indicate that most, if not all, of the CCK in the posterior pituitary and in the median eminence originates from the paraventricular nucleus. It appears that CCK-fibers, like other neuropeptidergic fibers from the paraventricular nucleus (vasopressin, oxytocin, TRH, CRF) enter the medial basal hypothalamus through a common gate-the lateral retrochiasmatic area-in travelling to the median eminence.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalBrain Research
Volume299
Issue number1
DOIs
Publication statusPublished - May 7 1984

Fingerprint

Hypothalamo-Hypophyseal System
Paraventricular Hypothalamic Nucleus
Cholecystokinin
Median Eminence
Middle Hypothalamus
Colchicine
Oxytocin
Vasopressins
Radioimmunoassay
Neurons

Keywords

  • cholecystokinin
  • hypothalamo-hypophyseal system
  • immunohistochemistry
  • lateral retrochiasmatic area
  • paraventricular nucleus
  • radioimmunoassay

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cholecystokinin in the hypothalamo-hypophyseal system. / Palkóvits, M.; Z. Kiss, József; Beinfeld, Margery C.; Brownstein, Michael J.

In: Brain Research, Vol. 299, No. 1, 07.05.1984, p. 186-189.

Research output: Contribution to journalArticle

Palkóvits, M, Z. Kiss, J, Beinfeld, MC & Brownstein, MJ 1984, 'Cholecystokinin in the hypothalamo-hypophyseal system', Brain Research, vol. 299, no. 1, pp. 186-189. https://doi.org/10.1016/0006-8993(84)90806-0
Palkóvits, M. ; Z. Kiss, József ; Beinfeld, Margery C. ; Brownstein, Michael J. / Cholecystokinin in the hypothalamo-hypophyseal system. In: Brain Research. 1984 ; Vol. 299, No. 1. pp. 186-189.
@article{5a1fae23bd9d4a149e3a04259ad50357,
title = "Cholecystokinin in the hypothalamo-hypophyseal system",
abstract = "Immunohistochemical studies on cholecystokinin-like (CCK-ir) substances in colchicine-pretreated rats demonstrated that in addition to CCK-ir cells in the magnocellular portion of the paraventricular nucleus, CCK-ir cells are also present among the parvocellular neurons. Radioimmunoassay of CCK after paraventricular lesions indicate that most, if not all, of the CCK in the posterior pituitary and in the median eminence originates from the paraventricular nucleus. It appears that CCK-fibers, like other neuropeptidergic fibers from the paraventricular nucleus (vasopressin, oxytocin, TRH, CRF) enter the medial basal hypothalamus through a common gate-the lateral retrochiasmatic area-in travelling to the median eminence.",
keywords = "cholecystokinin, hypothalamo-hypophyseal system, immunohistochemistry, lateral retrochiasmatic area, paraventricular nucleus, radioimmunoassay",
author = "M. Palk{\'o}vits and {Z. Kiss}, J{\'o}zsef and Beinfeld, {Margery C.} and Brownstein, {Michael J.}",
year = "1984",
month = "5",
day = "7",
doi = "10.1016/0006-8993(84)90806-0",
language = "English",
volume = "299",
pages = "186--189",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Cholecystokinin in the hypothalamo-hypophyseal system

AU - Palkóvits, M.

AU - Z. Kiss, József

AU - Beinfeld, Margery C.

AU - Brownstein, Michael J.

PY - 1984/5/7

Y1 - 1984/5/7

N2 - Immunohistochemical studies on cholecystokinin-like (CCK-ir) substances in colchicine-pretreated rats demonstrated that in addition to CCK-ir cells in the magnocellular portion of the paraventricular nucleus, CCK-ir cells are also present among the parvocellular neurons. Radioimmunoassay of CCK after paraventricular lesions indicate that most, if not all, of the CCK in the posterior pituitary and in the median eminence originates from the paraventricular nucleus. It appears that CCK-fibers, like other neuropeptidergic fibers from the paraventricular nucleus (vasopressin, oxytocin, TRH, CRF) enter the medial basal hypothalamus through a common gate-the lateral retrochiasmatic area-in travelling to the median eminence.

AB - Immunohistochemical studies on cholecystokinin-like (CCK-ir) substances in colchicine-pretreated rats demonstrated that in addition to CCK-ir cells in the magnocellular portion of the paraventricular nucleus, CCK-ir cells are also present among the parvocellular neurons. Radioimmunoassay of CCK after paraventricular lesions indicate that most, if not all, of the CCK in the posterior pituitary and in the median eminence originates from the paraventricular nucleus. It appears that CCK-fibers, like other neuropeptidergic fibers from the paraventricular nucleus (vasopressin, oxytocin, TRH, CRF) enter the medial basal hypothalamus through a common gate-the lateral retrochiasmatic area-in travelling to the median eminence.

KW - cholecystokinin

KW - hypothalamo-hypophyseal system

KW - immunohistochemistry

KW - lateral retrochiasmatic area

KW - paraventricular nucleus

KW - radioimmunoassay

UR - http://www.scopus.com/inward/record.url?scp=0021327697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021327697&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90806-0

DO - 10.1016/0006-8993(84)90806-0

M3 - Article

C2 - 6722568

AN - SCOPUS:0021327697

VL - 299

SP - 186

EP - 189

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -