Cholangiocarcinoma

Classification, Histopathology and Molecular Carcinogenesis

Gábor Lendvai, Tímea Szekerczés, Idikó Illyés, Réka Dóra, Endre Kontsek, Alíz Gógl, András Kiss, Klára Werling, I. Kovalszky, Z. Schaff, Katalin Borka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality worldwide. Several new classifications review the significance of tumor localization, site of origin, proliferation and biomarkers in the intrahepatic, perihilar and distal forms of the lesion. Based on growth pattern mass-forming, periductal-infiltrating, intraductal, undefined and mixed types are differentiated. There are further subclassifications which are applied for the histological features, in particular for intrahepatic CC. Recognition of the precursors and early lesions of CC including biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of the bile ducts (IPNB), biliary mucinous cystic neoplasm (MCNB) and the candidate precursors, such as bile duct adenoma and von Meyenburg complex is of increasing significance. In addition to the previously used biliary markers detected by immunohistochemistry, several new markers have been added to the differentiation of both the benign and malignant lesions, which can be used to aid in the subclassification in association with the outcome of CC. Major aspects of biliary carcinogenesis have been revealed, yet, the exact way of this diverse process is still unclear. The factors contributing to molecular cholangiocarcinogenesis include various risk factors, different anatomical localizations, multiple cellular origins, genetic and epigenetic alterations, tumor microenvironment, heterogeneity and clonal evolution. Driver mutations have been identified, implying that they are optimal candidates for targeted therapy. The most promising therapeutic candidates have entered clinical trials.

Original languageEnglish
JournalPathology and Oncology Research
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Cholangiocarcinoma
Carcinogenesis
Neoplasms
Bile Duct Adenoma
Bile Duct Neoplasms
Clonal Evolution
Tumor Microenvironment
Biliary Tract
Epigenomics
Biomarkers
Immunohistochemistry
Clinical Trials
Mutation
Mortality
Liver
Incidence
Therapeutics
Growth

Keywords

  • Biliary markers
  • Cholangiocarcinoma
  • Liver cancer
  • MicroRNA
  • Stem cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Lendvai, G., Szekerczés, T., Illyés, I., Dóra, R., Kontsek, E., Gógl, A., ... Borka, K. (Accepted/In press). Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis. Pathology and Oncology Research. https://doi.org/10.1007/s12253-018-0491-8

Cholangiocarcinoma : Classification, Histopathology and Molecular Carcinogenesis. / Lendvai, Gábor; Szekerczés, Tímea; Illyés, Idikó; Dóra, Réka; Kontsek, Endre; Gógl, Alíz; Kiss, András; Werling, Klára; Kovalszky, I.; Schaff, Z.; Borka, Katalin.

In: Pathology and Oncology Research, 01.01.2018.

Research output: Contribution to journalArticle

Lendvai, Gábor ; Szekerczés, Tímea ; Illyés, Idikó ; Dóra, Réka ; Kontsek, Endre ; Gógl, Alíz ; Kiss, András ; Werling, Klára ; Kovalszky, I. ; Schaff, Z. ; Borka, Katalin. / Cholangiocarcinoma : Classification, Histopathology and Molecular Carcinogenesis. In: Pathology and Oncology Research. 2018.
@article{9276c2fb1c7b4c1d902a201add93469a,
title = "Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis",
abstract = "Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality worldwide. Several new classifications review the significance of tumor localization, site of origin, proliferation and biomarkers in the intrahepatic, perihilar and distal forms of the lesion. Based on growth pattern mass-forming, periductal-infiltrating, intraductal, undefined and mixed types are differentiated. There are further subclassifications which are applied for the histological features, in particular for intrahepatic CC. Recognition of the precursors and early lesions of CC including biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of the bile ducts (IPNB), biliary mucinous cystic neoplasm (MCNB) and the candidate precursors, such as bile duct adenoma and von Meyenburg complex is of increasing significance. In addition to the previously used biliary markers detected by immunohistochemistry, several new markers have been added to the differentiation of both the benign and malignant lesions, which can be used to aid in the subclassification in association with the outcome of CC. Major aspects of biliary carcinogenesis have been revealed, yet, the exact way of this diverse process is still unclear. The factors contributing to molecular cholangiocarcinogenesis include various risk factors, different anatomical localizations, multiple cellular origins, genetic and epigenetic alterations, tumor microenvironment, heterogeneity and clonal evolution. Driver mutations have been identified, implying that they are optimal candidates for targeted therapy. The most promising therapeutic candidates have entered clinical trials.",
keywords = "Biliary markers, Cholangiocarcinoma, Liver cancer, MicroRNA, Stem cells",
author = "G{\'a}bor Lendvai and T{\'i}mea Szekercz{\'e}s and Idik{\'o} Illy{\'e}s and R{\'e}ka D{\'o}ra and Endre Kontsek and Al{\'i}z G{\'o}gl and Andr{\'a}s Kiss and Kl{\'a}ra Werling and I. Kovalszky and Z. Schaff and Katalin Borka",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s12253-018-0491-8",
language = "English",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Cholangiocarcinoma

T2 - Classification, Histopathology and Molecular Carcinogenesis

AU - Lendvai, Gábor

AU - Szekerczés, Tímea

AU - Illyés, Idikó

AU - Dóra, Réka

AU - Kontsek, Endre

AU - Gógl, Alíz

AU - Kiss, András

AU - Werling, Klára

AU - Kovalszky, I.

AU - Schaff, Z.

AU - Borka, Katalin

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality worldwide. Several new classifications review the significance of tumor localization, site of origin, proliferation and biomarkers in the intrahepatic, perihilar and distal forms of the lesion. Based on growth pattern mass-forming, periductal-infiltrating, intraductal, undefined and mixed types are differentiated. There are further subclassifications which are applied for the histological features, in particular for intrahepatic CC. Recognition of the precursors and early lesions of CC including biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of the bile ducts (IPNB), biliary mucinous cystic neoplasm (MCNB) and the candidate precursors, such as bile duct adenoma and von Meyenburg complex is of increasing significance. In addition to the previously used biliary markers detected by immunohistochemistry, several new markers have been added to the differentiation of both the benign and malignant lesions, which can be used to aid in the subclassification in association with the outcome of CC. Major aspects of biliary carcinogenesis have been revealed, yet, the exact way of this diverse process is still unclear. The factors contributing to molecular cholangiocarcinogenesis include various risk factors, different anatomical localizations, multiple cellular origins, genetic and epigenetic alterations, tumor microenvironment, heterogeneity and clonal evolution. Driver mutations have been identified, implying that they are optimal candidates for targeted therapy. The most promising therapeutic candidates have entered clinical trials.

AB - Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality worldwide. Several new classifications review the significance of tumor localization, site of origin, proliferation and biomarkers in the intrahepatic, perihilar and distal forms of the lesion. Based on growth pattern mass-forming, periductal-infiltrating, intraductal, undefined and mixed types are differentiated. There are further subclassifications which are applied for the histological features, in particular for intrahepatic CC. Recognition of the precursors and early lesions of CC including biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of the bile ducts (IPNB), biliary mucinous cystic neoplasm (MCNB) and the candidate precursors, such as bile duct adenoma and von Meyenburg complex is of increasing significance. In addition to the previously used biliary markers detected by immunohistochemistry, several new markers have been added to the differentiation of both the benign and malignant lesions, which can be used to aid in the subclassification in association with the outcome of CC. Major aspects of biliary carcinogenesis have been revealed, yet, the exact way of this diverse process is still unclear. The factors contributing to molecular cholangiocarcinogenesis include various risk factors, different anatomical localizations, multiple cellular origins, genetic and epigenetic alterations, tumor microenvironment, heterogeneity and clonal evolution. Driver mutations have been identified, implying that they are optimal candidates for targeted therapy. The most promising therapeutic candidates have entered clinical trials.

KW - Biliary markers

KW - Cholangiocarcinoma

KW - Liver cancer

KW - MicroRNA

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85056703498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056703498&partnerID=8YFLogxK

U2 - 10.1007/s12253-018-0491-8

DO - 10.1007/s12253-018-0491-8

M3 - Article

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

ER -