Chlamydia pneumoniae fiatal felnottek koszorúereiben

Translated title of the contribution: Chlamydia pneumoniae in coronary arteries of young adults

E. Hortoványi, G. Illyés, T. Glasz, J. Kulka, A. Kádár

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - An association of Chlamydia pneumoniae (C. pneumoniae) with coronary heart disease has been found with seroepidemiological methods. This organism was demonstrated in atheromatous plaques by electron microscopy, immunohistochemistry, and polymerase chain reaction. MATERIALS AND METHODS - To better understand the significance of the presence of C. pneumoniae in atheromatous plaques, we examined coronary artery segments from young adults (15-34 years) with and without atherosclerosis. 74 samples of left anterior descending artery were examined immunohistochemically for the presence of C. pneumoniae by the monoclonal antibody RR402. RESULT - C. pneumoniae was identified in the atheroma in 11 of 17 cases (65%) and in preatheroma in 6 of 15 cases (40%), in fatty streak in 7 of 23 cases (30%) and in intimal thickening in 1 of 14 cases (7%). C. pneumoniae was not found in the intimal and medial layer of the normal-appearing coronary arteries. C. pneumoniae was detected in the adventitia in 51 cases (67%) of the coronary arteries: in the normal arteries and initial lesions in 27 of 42 cases (63%), and in the advanced lesions in 24 of 32 cases (75%). Correlation was observed between the C. pneumoniae positive cases and cigarette smoking. CONCLUSION - Our results suggest that C. pneumoniae may relate to the severity of atherosclerosis in the youth, thus may initiate atherosclerotic injury or facilitate its progression along with other risk factors.

Original languageHungarian
Pages (from-to)542-547
Number of pages6
JournalLege Artis Medicinae
Volume11
Issue number8-9
Publication statusPublished - 2001

Fingerprint

Chlamydophila pneumoniae
Young Adult
Coronary Vessels
Atherosclerotic Plaques
Tunica Intima
Atherosclerosis
Arteries
Adventitia
Coronary Disease
Electron Microscopy
Smoking
Immunohistochemistry
Monoclonal Antibodies
Polymerase Chain Reaction
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chlamydia pneumoniae fiatal felnottek koszorúereiben. / Hortoványi, E.; Illyés, G.; Glasz, T.; Kulka, J.; Kádár, A.

In: Lege Artis Medicinae, Vol. 11, No. 8-9, 2001, p. 542-547.

Research output: Contribution to journalArticle

@article{92729a45068b43dd82122a3adc97c420,
title = "Chlamydia pneumoniae fiatal felnottek koszor{\'u}ereiben",
abstract = "INTRODUCTION - An association of Chlamydia pneumoniae (C. pneumoniae) with coronary heart disease has been found with seroepidemiological methods. This organism was demonstrated in atheromatous plaques by electron microscopy, immunohistochemistry, and polymerase chain reaction. MATERIALS AND METHODS - To better understand the significance of the presence of C. pneumoniae in atheromatous plaques, we examined coronary artery segments from young adults (15-34 years) with and without atherosclerosis. 74 samples of left anterior descending artery were examined immunohistochemically for the presence of C. pneumoniae by the monoclonal antibody RR402. RESULT - C. pneumoniae was identified in the atheroma in 11 of 17 cases (65{\%}) and in preatheroma in 6 of 15 cases (40{\%}), in fatty streak in 7 of 23 cases (30{\%}) and in intimal thickening in 1 of 14 cases (7{\%}). C. pneumoniae was not found in the intimal and medial layer of the normal-appearing coronary arteries. C. pneumoniae was detected in the adventitia in 51 cases (67{\%}) of the coronary arteries: in the normal arteries and initial lesions in 27 of 42 cases (63{\%}), and in the advanced lesions in 24 of 32 cases (75{\%}). Correlation was observed between the C. pneumoniae positive cases and cigarette smoking. CONCLUSION - Our results suggest that C. pneumoniae may relate to the severity of atherosclerosis in the youth, thus may initiate atherosclerotic injury or facilitate its progression along with other risk factors.",
keywords = "Atherosclerosis, Chlamydia pneumoniae, Coronary artery atherosclerosis, Fiatalok, Koszor{\'u}{\'e}r, Youth",
author = "E. Hortov{\'a}nyi and G. Illy{\'e}s and T. Glasz and J. Kulka and A. K{\'a}d{\'a}r",
year = "2001",
language = "Hungarian",
volume = "11",
pages = "542--547",
journal = "Lege Artis Medicinae",
issn = "0866-4811",
publisher = "Literatura Medica Publishing House",
number = "8-9",

}

TY - JOUR

T1 - Chlamydia pneumoniae fiatal felnottek koszorúereiben

AU - Hortoványi, E.

AU - Illyés, G.

AU - Glasz, T.

AU - Kulka, J.

AU - Kádár, A.

PY - 2001

Y1 - 2001

N2 - INTRODUCTION - An association of Chlamydia pneumoniae (C. pneumoniae) with coronary heart disease has been found with seroepidemiological methods. This organism was demonstrated in atheromatous plaques by electron microscopy, immunohistochemistry, and polymerase chain reaction. MATERIALS AND METHODS - To better understand the significance of the presence of C. pneumoniae in atheromatous plaques, we examined coronary artery segments from young adults (15-34 years) with and without atherosclerosis. 74 samples of left anterior descending artery were examined immunohistochemically for the presence of C. pneumoniae by the monoclonal antibody RR402. RESULT - C. pneumoniae was identified in the atheroma in 11 of 17 cases (65%) and in preatheroma in 6 of 15 cases (40%), in fatty streak in 7 of 23 cases (30%) and in intimal thickening in 1 of 14 cases (7%). C. pneumoniae was not found in the intimal and medial layer of the normal-appearing coronary arteries. C. pneumoniae was detected in the adventitia in 51 cases (67%) of the coronary arteries: in the normal arteries and initial lesions in 27 of 42 cases (63%), and in the advanced lesions in 24 of 32 cases (75%). Correlation was observed between the C. pneumoniae positive cases and cigarette smoking. CONCLUSION - Our results suggest that C. pneumoniae may relate to the severity of atherosclerosis in the youth, thus may initiate atherosclerotic injury or facilitate its progression along with other risk factors.

AB - INTRODUCTION - An association of Chlamydia pneumoniae (C. pneumoniae) with coronary heart disease has been found with seroepidemiological methods. This organism was demonstrated in atheromatous plaques by electron microscopy, immunohistochemistry, and polymerase chain reaction. MATERIALS AND METHODS - To better understand the significance of the presence of C. pneumoniae in atheromatous plaques, we examined coronary artery segments from young adults (15-34 years) with and without atherosclerosis. 74 samples of left anterior descending artery were examined immunohistochemically for the presence of C. pneumoniae by the monoclonal antibody RR402. RESULT - C. pneumoniae was identified in the atheroma in 11 of 17 cases (65%) and in preatheroma in 6 of 15 cases (40%), in fatty streak in 7 of 23 cases (30%) and in intimal thickening in 1 of 14 cases (7%). C. pneumoniae was not found in the intimal and medial layer of the normal-appearing coronary arteries. C. pneumoniae was detected in the adventitia in 51 cases (67%) of the coronary arteries: in the normal arteries and initial lesions in 27 of 42 cases (63%), and in the advanced lesions in 24 of 32 cases (75%). Correlation was observed between the C. pneumoniae positive cases and cigarette smoking. CONCLUSION - Our results suggest that C. pneumoniae may relate to the severity of atherosclerosis in the youth, thus may initiate atherosclerotic injury or facilitate its progression along with other risk factors.

KW - Atherosclerosis

KW - Chlamydia pneumoniae

KW - Coronary artery atherosclerosis

KW - Fiatalok

KW - Koszorúér

KW - Youth

UR - http://www.scopus.com/inward/record.url?scp=0034765778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034765778&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0034765778

VL - 11

SP - 542

EP - 547

JO - Lege Artis Medicinae

JF - Lege Artis Medicinae

SN - 0866-4811

IS - 8-9

ER -