Chirality of bioactive agents in protein binding storage and transport processes

Research output: Contribution to journalArticle

68 Citations (Scopus)


'Plasma protein binding can function as a biological machine that performs what pharmaceutical companies often neglect: the resolution of drugs into enantiomers'. The transport of drugs in the blood and into target cells, and storage of drugs, are all processes shown to exhibit stereoselectivity. Proteins being complex molecules that they are, this fact of life regarding carrier molecules should come as no surprise. Examples are not extensive, but stress the pharmacological importance of the resolution of racemic drugs into enantiomers by proteins. Miklos Simonyi and colleagues review specific examples of these phenomena.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalTrends in Pharmacological Sciences
Issue numberC
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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