Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH®, Chiralcel OJ-R® and Chirobiotic-T™® phases

Balázs Visegrády, Tünde Konecsni, Nina Grobuschek, Martin G. Schmid, F. Kilár, Hassan Y. Aboul-Enein, Gerald Gübitz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH®), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R®) and teicoplanin (Chirobiotic T™®) phases. All columns showed good chiral recognition ability for this class of compounds. Out of seven compounds investigated, six were resolved with baseline resolution with at least one of the three columns.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalJournal of Biochemical and Biophysical Methods
Volume53
Issue number1-3
DOIs
Publication statusPublished - Oct 2002

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Sodium Chloride Symporter Inhibitors
High Pressure Liquid Chromatography
Teicoplanin
Cellulose
cellulose tris-3,5-dimethylphenyl-carbamate
chirobiotic T
tris(4-methylbenzoate)cellulose
cellulose tris(4-methylbenzoate)
4-toluic acid

Keywords

  • Cellulose-based stationary phase
  • Diuretics
  • Enantiomer separation
  • Teicoplanin chiral stationary phase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH®, Chiralcel OJ-R® and Chirobiotic-T™® phases. / Visegrády, Balázs; Konecsni, Tünde; Grobuschek, Nina; Schmid, Martin G.; Kilár, F.; Aboul-Enein, Hassan Y.; Gübitz, Gerald.

In: Journal of Biochemical and Biophysical Methods, Vol. 53, No. 1-3, 10.2002, p. 15-24.

Research output: Contribution to journalArticle

Visegrády, Balázs ; Konecsni, Tünde ; Grobuschek, Nina ; Schmid, Martin G. ; Kilár, F. ; Aboul-Enein, Hassan Y. ; Gübitz, Gerald. / Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH®, Chiralcel OJ-R® and Chirobiotic-T™® phases. In: Journal of Biochemical and Biophysical Methods. 2002 ; Vol. 53, No. 1-3. pp. 15-24.
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AU - Konecsni, Tünde

AU - Grobuschek, Nina

AU - Schmid, Martin G.

AU - Kilár, F.

AU - Aboul-Enein, Hassan Y.

AU - Gübitz, Gerald

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