Chiral separation of deprenyl and its major metabolites using cyclodextrin-modified capillary zone electrophoresis

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Abstract

A capillary electrophoretic method for the enantiomer resolution of deprenyl and its main alkaline metabolites amphetamine, methamphetamine and propargylamphetamine is described. An acidic separation buffer with a suitable chiral complexing agent, heptakis-(2,6-di-O-methyl)-β-cyclodextrin, was used and the optimum separation conditions were determined by changing the concentration of the chiral selector, the applied electric field and the concentration of methanol.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalJournal of Chromatography A
Volume709
Issue number1
DOIs
Publication statusPublished - Aug 11 1995

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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