Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors

Nina Grobuschek, Lawan Sriphong, Martin G. Schmid, Tamàs Lorànd, Hassan Y. Aboul-Enein, Gerald Gübitz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or β-cyclodextrin were used and in CE different cyclodextrins, such as β-CD, γ-CD, carboxymethyl-β-CD and succinyl-β-CD were added to the background electrolyte as chiral selectors.

Original languageEnglish
Pages (from-to)25-36
Number of pages12
JournalJournal of biochemical and biophysical methods
Volume53
Issue number1-3
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Capillary electrophoresis
  • Cellulose derivative
  • Cyclodextrins
  • Enantiomer separation
  • High performance liquid chromatography
  • Mannich ketones

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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