Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors

Nina Grobuschek, Lawan Sriphong, Martin G. Schmid, T. Lóránd, Hassan Y. Aboul-Enein, Gerald Gübitz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or β-cyclodextrin were used and in CE different cyclodextrins, such as β-CD, γ-CD, carboxymethyl-β-CD and succinyl-β-CD were added to the background electrolyte as chiral selectors.

Original languageEnglish
Pages (from-to)25-36
Number of pages12
JournalJournal of Biochemical and Biophysical Methods
Volume53
Issue number1-3
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Cellulose derivatives
Cyclodextrins
Ketones
Cellulose
High Pressure Liquid Chromatography
Electrolytes
Pharmaceutical Preparations

Keywords

  • Capillary electrophoresis
  • Cellulose derivative
  • Cyclodextrins
  • Enantiomer separation
  • High performance liquid chromatography
  • Mannich ketones

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors. / Grobuschek, Nina; Sriphong, Lawan; Schmid, Martin G.; Lóránd, T.; Aboul-Enein, Hassan Y.; Gübitz, Gerald.

In: Journal of Biochemical and Biophysical Methods, Vol. 53, No. 1-3, 10.2002, p. 25-36.

Research output: Contribution to journalArticle

Grobuschek, Nina ; Sriphong, Lawan ; Schmid, Martin G. ; Lóránd, T. ; Aboul-Enein, Hassan Y. ; Gübitz, Gerald. / Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors. In: Journal of Biochemical and Biophysical Methods. 2002 ; Vol. 53, No. 1-3. pp. 25-36.
@article{6e3c381683b64bf0839c286fa22dcad8,
title = "Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors",
abstract = "The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or β-cyclodextrin were used and in CE different cyclodextrins, such as β-CD, γ-CD, carboxymethyl-β-CD and succinyl-β-CD were added to the background electrolyte as chiral selectors.",
keywords = "Capillary electrophoresis, Cellulose derivative, Cyclodextrins, Enantiomer separation, High performance liquid chromatography, Mannich ketones",
author = "Nina Grobuschek and Lawan Sriphong and Schmid, {Martin G.} and T. L{\'o}r{\'a}nd and Aboul-Enein, {Hassan Y.} and Gerald G{\"u}bitz",
year = "2002",
month = "10",
doi = "10.1016/S0165-022X(02)00089-1",
language = "English",
volume = "53",
pages = "25--36",
journal = "Journal of Proteomics",
issn = "1874-3919",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Chiral separation of bioactive cyclic Mannich ketones by HPLC and CE using cellulose derivatives and cyclodextrins as chiral selectors

AU - Grobuschek, Nina

AU - Sriphong, Lawan

AU - Schmid, Martin G.

AU - Lóránd, T.

AU - Aboul-Enein, Hassan Y.

AU - Gübitz, Gerald

PY - 2002/10

Y1 - 2002/10

N2 - The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or β-cyclodextrin were used and in CE different cyclodextrins, such as β-CD, γ-CD, carboxymethyl-β-CD and succinyl-β-CD were added to the background electrolyte as chiral selectors.

AB - The chiral separation of cyclic Mannich ketones of potential pharmaceutical interest is investigated using HPLC and CE. These Mannich ketones show a marked antibacterial and antifungal activity. In HPLC, stationary phases containing cellulose derivatives or β-cyclodextrin were used and in CE different cyclodextrins, such as β-CD, γ-CD, carboxymethyl-β-CD and succinyl-β-CD were added to the background electrolyte as chiral selectors.

KW - Capillary electrophoresis

KW - Cellulose derivative

KW - Cyclodextrins

KW - Enantiomer separation

KW - High performance liquid chromatography

KW - Mannich ketones

UR - http://www.scopus.com/inward/record.url?scp=0036803289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036803289&partnerID=8YFLogxK

U2 - 10.1016/S0165-022X(02)00089-1

DO - 10.1016/S0165-022X(02)00089-1

M3 - Article

C2 - 12406583

AN - SCOPUS:0036803289

VL - 53

SP - 25

EP - 36

JO - Journal of Proteomics

JF - Journal of Proteomics

SN - 1874-3919

IS - 1-3

ER -