Chiral selective separation of tocainide by capillary electrophoresis using various cyclodextrin derivatives

Zoltán Juvancz, Karin E. Markides, László Jicsinszky, Róbert Iványi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chiral separation of tocainide, an antiarrythmic agent, was solved using the capillary electrophoresis method. Fifteen types of cyclodextrins were tried as chiral selective buffer additives, and baseline separation was achieved with five of them. The variables that were studied comprise, type and concentration of the chiral selectors, pH of the buffers, and the organic modifiers. The best resolution, an Rs value of 5.2, was achieved using 7.5 mM γ-cyclodextrin phosphate at pH 6.8. Migration reversal of enantiomers was observed when changing the type of cyclodextrins. Not only the tocainide but also its by-product were enantiomericaly separated.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalJournal of Microcolumn Separations
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 1 2001

Keywords

  • Capillary electrophoresis
  • Chiral separation
  • Cyclodextrin selectors
  • Tocainide

ASJC Scopus subject areas

  • Mechanical Engineering
  • Filtration and Separation

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