Chiral recognition via host-guest interactions detected by fast-atom bombardment mass spectrometry

Principles and limitations

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

An intensity function combining peak intensities in the same manner as that in which equilibrium constants combine ion activities is suggested for characterization of enantioselectivity by fast-atom bombardment mass spectrometry. The intensity function combined with the use of two internal standards, one similar to the host, one to the guest compounds is shown to give excellent results: The enantioselectivity is better by up to factor of 10 than that obtained using one internal standard only, and its reproducibility is ca. a factor of 10 better, than that obtained using relative peak intensities (the RPI method).

Original languageEnglish
Pages (from-to)889-896
Number of pages8
JournalRapid Communications in Mass Spectrometry
Volume11
Issue number8
DOIs
Publication statusPublished - 1997

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Enantioselectivity
Mass spectrometry
Atoms
Equilibrium constants
Ions

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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abstract = "An intensity function combining peak intensities in the same manner as that in which equilibrium constants combine ion activities is suggested for characterization of enantioselectivity by fast-atom bombardment mass spectrometry. The intensity function combined with the use of two internal standards, one similar to the host, one to the guest compounds is shown to give excellent results: The enantioselectivity is better by up to factor of 10 than that obtained using one internal standard only, and its reproducibility is ca. a factor of 10 better, than that obtained using relative peak intensities (the RPI method).",
author = "A. Dob{\'o} and M. Lipt{\'a}k and P. Huszthy and K. V{\'e}key",
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T1 - Chiral recognition via host-guest interactions detected by fast-atom bombardment mass spectrometry

T2 - Principles and limitations

AU - Dobó, A.

AU - Lipták, M.

AU - Huszthy, P.

AU - Vékey, K.

PY - 1997

Y1 - 1997

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AB - An intensity function combining peak intensities in the same manner as that in which equilibrium constants combine ion activities is suggested for characterization of enantioselectivity by fast-atom bombardment mass spectrometry. The intensity function combined with the use of two internal standards, one similar to the host, one to the guest compounds is shown to give excellent results: The enantioselectivity is better by up to factor of 10 than that obtained using one internal standard only, and its reproducibility is ca. a factor of 10 better, than that obtained using relative peak intensities (the RPI method).

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EP - 896

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